| Round | Overall | Player |
|---|---|---|
| 1 | 12th | RB Rudi Johnson Cin |
| 2 | 13th | RB Laurence Maroney NE |
| 3 | 36th | WR Anquan Boldin Ari |
| 4 | 37th | TE Antonio Gates SD |
| 5 | 60th | QB Philip Rivers SD |
| 6 | 61st | WR Braylon Edwards Cle |
| 7 | 84th | RB DeAngelo Williams Car |
| 8 | 85th | LB A.J. Hawk GB |
| 9 | 108th | DL Terrell Suggs Bal |
| 10 | 109th | QB Alex Smith SF |
| 11 | 132nd | LB Mike Peterson Jac |
| 12 | 133rd | S Roy Williams Dal |
| 13 | 156th | DL Mario Williams Hou |
| 14 | 157th | WR Anthony Gonzalez Ind |
| 15 | 180th | RB LenDale White Ten |
| 16 | 181st | S Bob Sanders Ind |
| 17 | 204th | TE Greg Olsen Chi |
| 18 | 205th | DL Trevor Pryce Bal |
| 19 | 228th | PK David Akers Phi |
| 20 | 229th | CB Dre Bly Den |
| 21 | 252nd | QB Tarvaris Jackson Min |
| 22 | 253rd | LB Takeo Spikes Phi |
| 23 | 276th | PK Joe Nedney SF |
| 24 | 277th | WR Patrick Crayton Dal |
| 25 | 300th | LB Chike Okeafor F/A |
| 26 | 301st | DL Greg Ellis Dal |
| 27 | 324th | WR Steve Smith NYG |
| 28 | 325th | CB Lito Sheppard Phi |