| Round | Overall | Player |
|---|---|---|
| 1 | 9th | RB Reggie Bush NO |
| 2 | 16th | RB Maurice Jones-Drew Jac |
| 3 | 33rd | RB Carnell Williams F/A |
| 4 | 40th | RB Thomas Jones NYJ |
| 5 | 57th | QB Philip Rivers SD |
| 6 | 64th | QB Tony Romo Dal |
| 7 | 81st | RB Tatum Bell Det |
| 8 | 88th | WR Vincent Jackson SD |
| 9 | 105th | WR Jerricho Cotchery NYJ |
| 10 | 112th | WR Santonio Holmes Pit |
| 11 | 129th | RB Vernand Morency GB |
| 12 | 136th | TE Jason Witten Dal |
| 13 | 153rd | S Sean Jones Cle |
| 14 | 160th | QB Matt Schaub Hou |
| 15 | 177th | LB Paul Posluszny F/A |
| 16 | 184th | LB Erin Henderson Min |
| 17 | 201st | PK Nate Kaeding SD |
| 18 | 208th | RB Adrian Peterson Chi |
| 19 | 225th | RB Sammy Morris NE |
| 20 | 232nd | LB Kamerion Wimbley Cle |
| 21 | 249th | TE Zach Miller Oak |
| 22 | 256th | DL Patrick Kerney Sea |
| 23 | 273rd | WR Dwayne Jarrett Car |
| 24 | 280th | DL Robert Geathers Cin |
| 25 | 297th | RB Tony Hunt Phi |
| 26 | 304th | S Eric Weddle SD |
| 27 | 321st | DL LaMarr Woodley Pit |
| 28 | 328th | CB Ivan Taylor Pit |