| Round | Overall | Player |
|---|---|---|
| 1 | 11th | RB Clinton Portis Was |
| 2 | 14th | RB Marshawn Lynch Buf |
| 3 | 35th | RB Willis McGahee Bal |
| 4 | 38th | WR Calvin Johnson Det |
| 5 | 59th | TE Kellen Winslow Jr. Cle |
| 6 | 62nd | QB Ben Roethlisberger Pit |
| 7 | 83rd | LB Demarcus Ware Dal |
| 8 | 86th | DL Julius Peppers Car |
| 9 | 107th | CB Antonio Cromartie SD |
| 10 | 110th | S Adrian Wilson Ari |
| 11 | 131st | WR Anthony Gonzalez Ind |
| 12 | 134th | WR DeSean Jackson Phi |
| 13 | 155th | RB Tim Hightower Ari |
| 14 | 158th | DL Gaines Adams TB |
| 15 | 179th | LB James Harrison Pit |
| 16 | 182nd | LB Keith Bulluck Ten |
| 17 | 203rd | RB Ladell Betts Was |
| 18 | 206th | PK Nicholas Folk Dal |
| 19 | 227th | QB Jeff Garcia TB |
| 20 | 230th | WR Josh Morgan SF |
| 21 | 251st | S Troy Polamalu Pit |
| 22 | 254th | TE Dustin Keller NYJ |
| 23 | 275th | DL Darryl Tapp Sea |
| 24 | 278th | WR Limas Sweed Pit |
| 25 | 299th | CB Leodis McKelvin Buf |
| 26 | 302nd | WR Courtney Taylor Sea |
| 27 | 323rd | RB Mike Hart Ind |
| 28 | 326th | LB Shawne Merriman SD |