| Round | Overall | Player |
|---|---|---|
| 1 | 7th | RB Frank Gore SF |
| 2 | 18th | WR Braylon Edwards Cle |
| 3 | 31st | RB Darren McFadden Oak |
| 4 | 42nd | LB Patrick Willis SF |
| 5 | 55th | TE Antonio Gates SD |
| 6 | 66th | QB Derek Anderson Cle |
| 7 | 79th | WR Jerry Porter Jac |
| 8 | 90th | LB Jon Beason Car |
| 9 | 103rd | RB Ronnie Brown Mia |
| 10 | 114th | RB Rashard Mendenhall Pit |
| 11 | 127th | DL Kyle Vanden Bosch Ten |
| 12 | 138th | QB Matt Leinart Ari |
| 13 | 151st | DL Darnell Dockett Ari |
| 14 | 162nd | QB Philip Rivers SD |
| 15 | 175th | WR Javon Walker Oak |
| 16 | 186th | TE Randy McMichael StL |
| 17 | 199th | S Oshiomogho Atogwe StL |
| 18 | 210th | LB David Thornton Ten |
| 19 | 223rd | WR James Hardy Buf |
| 20 | 234th | PK Josh Brown StL |
| 21 | 247th | S Clinton Hart SD |
| 22 | 258th | RB DeShaun Foster SF |
| 23 | 271st | CB Nick Harper Ten |
| 24 | 282nd | DL Paul Spicer Jac |
| 25 | 295th | WR Marty Booker Chi |
| 26 | 306th | RB Ryan Torain Den |
| 27 | 319th | CB Anthony Henry Dal |
| 28 | 330th | LB Bradie James Dal |