| Round | Overall | Player |
|---|---|---|
| 1 | 7th | RB Joseph Addai Ind |
| 2 | 18th | QB Drew Brees NO |
| 3 | 31st | WR Roy Williams Dal |
| 4 | 42nd | WR Calvin Johnson Det |
| 5 | 55th | WR Lee Evans Buf |
| 6 | 66th | TE Dallas Clark Ind |
| 7 | 79th | QB Philip Rivers SD |
| 8 | 90th | WR Santana Moss Was |
| 9 | 103rd | WR Anthony Gonzalez Ind |
| 10 | 114th | LB James Harrison Pit |
| 11 | 127th | LB Erin Henderson Min |
| 12 | 138th | S Chris Harris Car |
| 13 | 151st | CB Leigh Bodden Det |
| 14 | 162nd | DL Adewale Ogunleye Chi |
| 15 | 175th | DL Elvis Dumervil Den |
| 16 | 186th | RB Dominic Rhodes Ind |
| 17 | 199th | PK Nicholas Folk Dal |
| 18 | 210th | QB Trent Edwards Buf |
| 19 | 223rd | WR Devin Hester Chi |
| 20 | 234th | LB Angelo Crowell Buf |
| 21 | 247th | S Oshiomogho Atogwe StL |
| 22 | 258th | CB Terrence McGee Buf |
| 23 | 271st | DL Dewayne White Det |
| 24 | 282nd | TE Leonard Pope Ari |
| 25 | 295th | LB Michael Boley Atl |
| 26 | 306th | DL Shaun Rogers Cle |
| 27 | 319th | RB Kolby Smith KC |
| 28 | 330th | WR Devin Thomas Was |