| Round | Overall | Player |
|---|---|---|
| 1 | 3rd | RB Steven Jackson StL |
| 2 | 22nd | QB Drew Brees NO |
| 3 | 27th | RB Jamal Lewis Cle |
| 4 | 46th | WR T.J. Houshmandzadeh Cin |
| 5 | 51st | WR Roy Williams Dal |
| 6 | 70th | LB Patrick Willis SF |
| 7 | 75th | TE Chris Cooley Was |
| 8 | 94th | CB Chris Johnson Oak |
| 9 | 99th | DL Patrick Kerney Sea |
| 10 | 118th | WR Donald Driver GB |
| 11 | 123rd | RB Steve Slaton Hou |
| 12 | 142nd | LB Will Witherspoon StL |
| 13 | 147th | QB Matt Schaub Hou |
| 14 | 166th | RB Andre Hall Den |
| 15 | 171st | DL Adewale Ogunleye Chi |
| 16 | 190th | CB Richard Marshall Car |
| 17 | 195th | S Michael Lewis SF |
| 18 | 214th | WR Javon Walker Oak |
| 19 | 219th | PK Nate Kaeding SD |
| 20 | 238th | TE Tony Scheffler Den |
| 21 | 243rd | DL Kelly Gregg Bal |
| 22 | 262nd | LB Chad Greenway Min |
| 23 | 267th | CB Terrence McGee Buf |
| 24 | 286th | WR Kevin Curtis Phi |
| 25 | 291st | S Roy Williams Dal |
| 26 | 310th | RB Shaun Alexander Was |
| 27 | 315th | PK John Kasay Car |
| 28 | 334th | WR Devin Hester Chi |