| Round | Overall | Player |
|---|---|---|
| 1 | 8th | RB Frank Gore SF |
| 2 | 17th | RB Brian Westbrook Phi |
| 3 | 32nd | WR Anquan Boldin Bal |
| 4 | 41st | QB Tony Romo Dal |
| 5 | 56th | RB Joseph Addai Ind |
| 6 | 65th | WR Devin Hester Chi |
| 7 | 80th | WR Antonio Bryant Cin |
| 8 | 89th | LB Dave Harris NYJ |
| 9 | 104th | RB Rashard Mendenhall Pit |
| 10 | 113th | WR Torry Holt NE |
| 11 | 128th | DL Robert Mathis Ind |
| 12 | 137th | QB Kyle Orton Den |
| 13 | 152nd | RB Edgerrin James F/A |
| 14 | 161st | LB Keith Rivers Cin |
| 15 | 176th | S Quintin Mikell Phi |
| 16 | 185th | QB Matt Cassel KC |
| 17 | 200th | WR Justin Gage Ten |
| 18 | 209th | TE Jermichael Finley GB |
| 19 | 224th | TE Vernon Davis SF |
| 20 | 233rd | DL Chris Long StL |
| 21 | 248th | LB Lawrence Timmons Pit |
| 22 | 257th | QB Brady Quinn Den |
| 23 | 272nd | DL Will Smith NO |
| 24 | 281st | RB Sammy Morris NE |
| 25 | 296th | CB Aqib Talib TB |
| 26 | 305th | PK Josh Scobee Jac |
| 27 | 320th | LB Derrick Johnson KC |
| 28 | 329th | DL Ray Edwards Min |