| Round | Overall | Player |
|---|---|---|
| 1 | 7th | RB Steven Jackson StL |
| 2 | 18th | WR Steve Smith Car |
| 3 | 31st | WR Wesley Welker NE |
| 4 | 42nd | RB Darren McFadden Oak |
| 5 | 55th | RB Reggie Bush NO |
| 6 | 66th | WR Eddie Royal Den |
| 7 | 79th | QB Jay Cutler Chi |
| 8 | 90th | LB Jon Beason Car |
| 9 | 103rd | LB Jerod Mayo NE |
| 10 | 114th | RB Chester Taylor Chi |
| 11 | 127th | S Eric Weddle SD |
| 12 | 138th | DL Robert Mathis Ind |
| 13 | 151st | TE Zach Miller Jac |
| 14 | 162nd | TE Jeremy Shockey NO |
| 15 | 175th | WR Josh Morgan SF |
| 16 | 186th | QB Jake Delhomme Cle |
| 17 | 199th | RB Peyton Hillis Cle |
| 18 | 210th | DL Chris Long StL |
| 19 | 223rd | LB Brian Urlacher Chi |
| 20 | 234th | CB Charles Woodson GB |
| 21 | 247th | PK Nate Kaeding SD |
| 22 | 258th | WR Nate Burleson Det |
| 23 | 271st | RB Mike Bell Phi |
| 24 | 282nd | RB Brandon Jackson GB |
| 25 | 295th | CB Champ Bailey Den |
| 26 | 306th | S Chris Horton Was |
| 27 | 319th | PK Adam Vinatieri Ind |
| 28 | 330th | QB Byron Leftwich Pit |