| Round | Overall | Player |
|---|---|---|
| 1 | 12th | WR Andre Johnson Hou |
| 2 | 13th | WR Calvin Johnson Det |
| 3 | 36th | RB Ronnie Brown Mia |
| 4 | 37th | RB Darren McFadden Oak |
| 5 | 60th | QB Carson Palmer Cin |
| 6 | 61st | LB Karlos Dansby Mia |
| 7 | 84th | RB Thomas Jones KC |
| 8 | 85th | QB Matt Schaub Hou |
| 9 | 108th | S Edward Reed Bal |
| 10 | 109th | LB LaMarr Woodley Pit |
| 11 | 132nd | CB Darrelle Revis NYJ |
| 12 | 133rd | TE Dustin Keller NYJ |
| 13 | 156th | DL Adewale Ogunleye Chi |
| 14 | 157th | WR Steve Breaston Ari |
| 15 | 180th | DL Dwight Freeney Ind |
| 16 | 181st | WR Nate Burleson Det |
| 17 | 204th | PK Rob Bironas Ten |
| 18 | 205th | CB Cortland Finnegan Ten |
| 19 | 228th | TE Kevin Boss NYG |
| 20 | 229th | LB Julian Peterson Det |
| 21 | 252nd | PK Robbie Gould Chi |
| 22 | 253rd | DL Alex Brown NO |
| 23 | 276th | RB Sammy Morris NE |
| 24 | 277th | QB Brady Quinn Den |
| 25 | 300th | RB Jamaal Charles KC |
| 26 | 301st | WR Sidney Rice Min |
| 27 | 324th | LB Keith Bulluck NYG |
| 28 | 325th | S Chris Hope Ten |