| Round | Overall | Player |
|---|---|---|
| 1 | 2nd | RB Adrian Peterson Min |
| 2 | 23rd | WR Greg Jennings GB |
| 3 | 26th | WR Hakeem Nicks NYG |
| 4 | 47th | RB Fred Jackson Buf |
| 5 | 50th | QB Ben Roethlisberger Pit |
| 6 | 71st | DL Julius Peppers Chi |
| 7 | 74th | WR Santonio Holmes NYJ |
| 8 | 95th | QB Sam Bradford StL |
| 9 | 98th | LB Barrett Ruud Ten |
| 10 | 119th | RB C.J. Spiller Buf |
| 11 | 122nd | RB Pierre Thomas Jr. NO |
| 12 | 143rd | DL Chris Long StL |
| 13 | 146th | TE Tony Gonzalez Atl |
| 14 | 167th | S Patrick Chung NE |
| 15 | 170th | LB David Hawthorne Sea |
| 16 | 191st | WR Kevin Walter Hou |
| 17 | 194th | LB Karlos Dansby Mia |
| 18 | 215th | CB Tramon Williams GB |
| 19 | 218th | TE Brandon Pettigrew Det |
| 20 | 239th | PK Neil Rackers Hou |
| 21 | 242nd | RB Toby Gerhart Min |
| 22 | 263rd | WR James Jones GB |
| 23 | 266th | LB Joe Mays Den |
| 24 | 287th | CB Antoine Winfield Min |
| 25 | 290th | PK Shaun Suisham Pit |
| 26 | 311th | WR Steve Breaston KC |
| 27 | 314th | DL Adrian Clayborn TB |
| 28 | 335th | DL Dwan Edwards Buf |