| Round | Overall | Player |
|---|---|---|
| 1 | 8th | RB LeSean McCoy Phi |
| 2 | 17th | QB Drew Brees NO |
| 3 | 32nd | LB Patrick Willis SF |
| 4 | 41st | RB Ryan Mathews SD |
| 5 | 56th | WR Mario Manningham NYG |
| 6 | 65th | TE Jimmy Graham NO |
| 7 | 80th | LB Derrick Johnson KC |
| 8 | 89th | WR Austin Collie Ind |
| 9 | 104th | DL Matt Shaughnessy F/A |
| 10 | 113th | QB Mark Sanchez NYJ |
| 11 | 128th | DL Kyle Williams F/A |
| 12 | 137th | WR Lee Evans Bal |
| 13 | 152nd | S Eric Weddle SD |
| 14 | 161st | RB Marion Barber Chi |
| 15 | 176th | WR Danny Amendola StL |
| 16 | 185th | LB Jonathan Vilma NO |
| 17 | 200th | WR Johnny Knox Chi |
| 18 | 209th | S Roman Harper NO |
| 19 | 224th | DL Antonio Garay SD |
| 20 | 233rd | PK Garrett Hartley F/A |
| 21 | 248th | RB Darren Sproles NO |
| 22 | 257th | TE Heath Miller Pit |
| 23 | 272nd | CB Nate Clements Cin |
| 24 | 281st | LB Brian Cushing Hou |
| 25 | 296th | RB Larry Johnson Mia |
| 26 | 305th | WR Eddie Royal SD |
| 27 | 320th | CB Antoine Cason SD |
| 28 | 329th | QB Kerry Collins Ind |