| Round | Overall | Player |
|---|---|---|
| 1 | 12th | RB Rashard Mendenhall Pit |
| 2 | 13th | WR Calvin Johnson Det |
| 3 | 36th | RB Jahvid Best Det |
| 4 | 37th | RB Mark Ingram NO |
| 5 | 60th | TE Jason Witten Dal |
| 6 | 61st | WR Percy Harvin Min |
| 7 | 84th | QB Matthew Stafford Det |
| 8 | 85th | RB Joseph Addai Ind |
| 9 | 108th | QB Kevin Kolb Ari |
| 10 | 109th | WR Steve Smith Car |
| 11 | 132nd | WR Michael Crabtree SF |
| 12 | 133rd | DL John Abraham Atl |
| 13 | 156th | LB D'Qwell Jackson Cle |
| 14 | 157th | LB Rey Maualuga Cin |
| 15 | 180th | LB Von Miller Den |
| 16 | 181st | RB LaDainian Tomlinson NYJ |
| 17 | 204th | DL Ray Edwards Atl |
| 18 | 205th | RB Alex Green GB |
| 19 | 228th | RB Carnell Williams StL |
| 20 | 229th | RB Isaac Redman Pit |
| 21 | 252nd | QB Andy Dalton Cin |
| 22 | 253rd | PK David Buehler Dal |
| 23 | 276th | TE Martellus Bennett Dal |
| 24 | 277th | WR Riley Cooper Phi |
| 25 | 300th | QB John Beck Hou |
| 26 | 301st | S Louis Delmas Det |
| 27 | 324th | S Kenny Phillips NYG |
| 28 | 325th | CB Kelvin Hayden Atl |