| Round | Overall | Player |
|---|---|---|
| 1 | 7th | QB Drew Brees NO |
| 2 | 18th | WR Greg Jennings GB |
| 3 | 31st | RB Peyton Hillis KC |
| 4 | 42nd | WR Anquan Boldin Bal |
| 5 | 55th | RB Ryan Mathews SD |
| 6 | 66th | LB London Fletcher Was |
| 7 | 79th | WR Nate Burleson Det |
| 8 | 90th | LB Brian Urlacher Chi |
| 9 | 103rd | TE Kellen Winslow Jr. Sea |
| 10 | 114th | LB Chad Greenway Min |
| 11 | 127th | TE Brandon Pettigrew Det |
| 12 | 138th | DL Calais Campbell Ari |
| 13 | 151st | QB Ryan Fitzpatrick Buf |
| 14 | 162nd | S Donte Whitner SF |
| 15 | 175th | DL James Hall StL |
| 16 | 186th | CB Brent Grimes Atl |
| 17 | 199th | WR Danny Amendola StL |
| 18 | 210th | PK Nate Kaeding SD |
| 19 | 223rd | RB DeMarco Murray Dal |
| 20 | 234th | DL Israel Idonije Chi |
| 21 | 247th | WR Titus Young Det |
| 22 | 258th | LB A.J. Hawk GB |
| 23 | 271st | S Michael Huff Oak |
| 24 | 282nd | RB Danny Woodhead NE |
| 25 | 295th | WR Kevin Walter Hou |
| 26 | 306th | CB Glover Quin Hou |
| 27 | 319th | WR Devin Hester Chi |
| 28 | 330th | LB Casey Matthews Phi |