| Round | Overall | Player |
|---|---|---|
| 1 | 11th | WR Calvin Johnson Det |
| 2 | 14th | RB Darren McFadden Oak |
| 3 | 35th | RB Knowshon Moreno Den |
| 4 | 38th | WR Reggie Wayne Ind |
| 5 | 59th | TE Jason Witten Dal |
| 6 | 62nd | LB Jerod Mayo NE |
| 7 | 83rd | QB Kevin Kolb Ari |
| 8 | 86th | WR Sidney Rice Min |
| 9 | 107th | RB BenJarvus Green-Ellis NE |
| 10 | 110th | DL Charles Johnson Car |
| 11 | 131st | RB Pierre Thomas Jr. NO |
| 12 | 134th | WR Lance Moore NO |
| 13 | 155th | S Tyvon Branch Oak |
| 14 | 158th | LB Jonathan Vilma NO |
| 15 | 179th | DL Carlos Dunlap Cin |
| 16 | 182nd | CB Devin McCourty NE |
| 17 | 203rd | WR Johnny Knox Chi |
| 18 | 206th | TE Lance Kendricks StL |
| 19 | 227th | QB Chad Henne Jac |
| 20 | 230th | QB John Beck Hou |
| 21 | 251st | DL Ray Edwards Atl |
| 22 | 254th | TE Todd Heap Ari |
| 23 | 275th | LB Brian Orakpo Was |
| 24 | 278th | RB Tashard Choice Buf |
| 25 | 299th | CB Champ Bailey Den |
| 26 | 302nd | PK Billy Cundiff Bal |
| 27 | 323rd | S Oshiomogho Atogwe Was |
| 28 | 326th | RB Isaac Redman Pit |