| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Atl | 23 | |
| C.J. Cron | 1B (DH) | Col | 31 | |
| Dom Smith | 1B (OF) | NYN | 26 | |
| Andrew Vaughn | 1B (OF,DH) | ChA | 23 | |
| Brandon Lowe | 2B (OF,DH) | TB | 27 | |
| Danny Mendick | 2B (3B,SS,OF) | ChA | 27 | |
| Jean Segura | 2B | Phi | 31 | |
| Jeter Downs | SS | Bos | 23 | |
| Marco Luciano | SS | SF | 20 | |
| Andrelton Simmons | SS | Min | 32 | |
| Jose Ramirez | 3B (DH) | Cle | 29 | |
| Abraham Toro | 3B (2B) | Sea | 24 | |
| Akil Baddoo | OF (DH) | Det | 23 | |
| Steven Duggar | OF | SF | 27 | |
| Teoscar Hernández | OF (DH) | Tor | 28 | |
| Max Kepler | OF (DH) | Min | 28 | |
| Starling Marte | OF | Oak | 32 | |
| Rafael Ortega | OF | ChN | 30 | |
| Anthony Santander | OF (DH) | Bal | 26 | |
| Jorge Soler | OF (DH) | Atl | 28 | |
| Giancarlo Stanton | OF (DH) | NYA | 31 | |
| Justin Upton | OF | LAA | 34 | September 05, 2021:10 Day IL-Right lumbar strain |
| Danny Duffy | SP | LAD | 32 | July 20, 2021:10 Day IL-Left flexor strain |
| Kendall Graveman | SP (RP) | Hou | 30 | |
| Adrian Houser | SP (RP) | Mil | 28 | |
| Michael Kopech | SP (RP) | ChA | 25 | |
| Alek Manoah | SP | Tor | 23 | |
| Wily Peralta | SP | Det | 32 | |
| Chris Sale | SP | Bos | 32 | |
| Stephen Strasburg | SP | Was | 33 | June 02, 2021:10 Day IL-Neck strain |
| Noah Syndergaard | SP | NYN | 29 | February 20, 2021:60 Day IL-Recovery from right elbow surgery |
| Framber Valdez | SP | Hou | 27 | |
| Daniel Bard | RP | Col | 36 | |
| Richard RodrÃguez | RP | Atl | 31 |