| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 25 | June 20, 2025:10 Day IL |
| Tyler Stephenson | C | Cin | 28 | |
| Pete Alonso | 1B | NYN | 30 | |
| C.J. Kayfus | 1B | Cle | 23 | |
| Zack Gelof | 2B | Oak | 25 | |
| Zach McKinstry | 2B (SS,3B,OF) | Det | 30 | |
| Marcus Semien | 2B | Tex | 34 | |
| Wander Franco | SS | TB | 24 | |
| Aidan Miller | SS | Phi | 21 | |
| Colson Montgomery | SS | ChA | 23 | |
| Max Muncy | SS (2B,3B) | Oak | 22 | |
| Ezequiel Tovar | SS | Col | 23 | June 06, 2025:10 Day IL |
| JJ Wetherholt | SS | StL | 22 | |
| Ernie Clement | 3B (1B,2B,SS) | Tor | 29 | |
| Maikel Garcia | 3B (2B,SS,OF) | KC | 25 | |
| Royce Lewis | 3B | Min | 26 | |
| Yordan Alvarez | OF | Hou | 28 | May 05, 2025:60 Day IL |
| Sal Frelick | OF | Mil | 25 | |
| Austin Hays | OF | Cin | 30 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Pat Corbin | SP | Tex | 35 | |
| Bailey Falter | SP | Pit | 28 | |
| Hunter Greene | SP | Cin | 25 | June 04, 2025:15 Day IL |
| DL Hall | SP (RP) | Mil | 26 | |
| Emerson Hancock | SP | Sea | 26 | |
| Adrian Houser | SP | ChA | 32 | |
| Nick Lodolo | SP | Cin | 27 | |
| Rhett Lowder | SP | Cin | N/A | March 26, 2025:60 Day IL |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Kumar Rocker | SP | Tex | N/A | |
| Logan Webb | SP | SF | 28 | |
| Simeon Woods Richardson | SP | Min | 24 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Will Vest | RP | Det | 30 |