| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Edgar Quero | C | ChA | 22 | |
| Kyle Teel | C | ChA | 23 | |
| Pete Alonso | 1B | NYN | 30 | |
| C.J. Kayfus | 1B (OF) | Cle | 24 | |
| Zach McKinstry | 2B (SS,3B,OF) | Det | 30 | |
| Marcus Semien | 2B | Tex | 35 | August 23, 2025:60 Day IL |
| Willy Adames | SS | SF | 30 | |
| Wander Franco | SS | TB | 24 | |
| Aidan Miller | SS | Phi | 21 | |
| Colson Montgomery | SS (3B) | ChA | 23 | |
| Ezequiel Tovar | SS | Col | 24 | |
| JJ Wetherholt | SS | StL | 23 | |
| Ernie Clement | 3B (1B,2B,SS) | Tor | 29 | |
| Maikel Garcia | 3B (2B,SS,OF) | KC | 25 | |
| Royce Lewis | 3B | Min | 26 | |
| Yordan Alvarez | OF | Hou | 28 | September 19, 2025:10 Day IL |
| Sal Frelick | OF | Mil | 25 | |
| Drew Gilbert | OF | SF | 25 | |
| Josh Lowe | OF | TB | 27 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Hunter Greene | SP | Cin | 26 | |
| DL Hall | SP (RP) | Mil | 27 | August 16, 2025:15 Day IL |
| Cade Horton | SP | ChN | 24 | September 27, 2025:15 Day IL |
| Adrian Houser | SP | TB | 32 | |
| Jack Leiter | SP | Tex | N/A | |
| Nick Lodolo | SP | Cin | 27 | |
| Jacob Lopez | SP (RP) | Oak | N/A | August 26, 2025:15 Day IL |
| Rhett Lowder | SP | Cin | N/A | |
| Zebby Matthews | SP | Min | N/A | |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Kumar Rocker | SP | Tex | N/A | |
| Logan Webb | SP | SF | 28 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Will Vest | RP | Det | 30 |