| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Eric Haase | C (OF,DH) | Det | 28 | |
| Jesus Aguilar | 1B (DH) | Mia | 31 | September 08, 2021:10 Day IL-Left knee inflammation |
| Miguel Sano | 1B (3B,DH) | Min | 28 | |
| Luke Voit | 1B (DH) | NYA | 30 | |
| Jared Walsh | 1B (OF) | LAA | 28 | |
| Cesar Hernández | 2B (DH) | ChA | 31 | |
| Ryan McMahon | 2B (3B) | Col | 26 | |
| Jurickson Profar | 2B (1B,OF) | SD | 28 | |
| Miguel Rojas | SS | Mia | 32 | |
| Luis Urias | SS (2B,3B) | Mil | 24 | |
| Miguel Andújar | 3B (OF) | NYA | 26 | July 07, 2021:10 Day IL-Strained left wrist |
| Bobby Dalbec | 3B (1B) | Bos | 26 | |
| Carter Kieboom | 3B | Was | 24 | |
| Jose Ramirez | 3B (DH) | Cle | 29 | |
| Abraham Toro | 3B (2B) | Sea | 24 | |
| Yordan Alvarez | OF (DH) | Hou | 24 | |
| J.D. Davis | OF (3B) | NYN | 28 | September 26, 2021:10 Day IL-Sprained left hand |
| Jasson Dominguez | OF | NYA | 18 | |
| Jarren Duran | OF | Bos | 25 | |
| Lourdes Gurriel | OF (1B,DH) | Tor | 27 | |
| Justin Upton | OF | LAA | 34 | September 05, 2021:10 Day IL-Right lumbar strain |
| MacKenzie Gore | SP | SD | 22 | |
| Kendall Graveman | SP (RP) | Hou | 30 | |
| Michael Kopech | SP (RP) | ChA | 25 | |
| Dustin May | SP | LAD | 24 | May 02, 2021:10 Day IL-Right arm injury |
| Casey Mize | SP | Det | 24 | |
| Wily Peralta | SP | Det | 32 | |
| Drew Smyly | SP (RP) | Atl | 32 | |
| Logan Webb | SP | SF | 24 | |
| Jake Woodford | SP (RP) | StL | 24 | |
| Luis Garcia | RP (SP) | Hou | 24 | |
| Brad Hand | RP | NYN | 31 | |
| Jacob McGee | RP | SF | 35 | September 14, 2021:10 Day IL-Strained right oblique |
| Richard Rodríguez | RP | Atl | 31 |