| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Sean Murphy | C | Atl | 31 | September 08, 2025:60 Day IL |
| J.T. Realmuto | C | Phi | 34 | |
| Adley Rutschman | C | Bal | 27 | |
| Luis Arraez | 1B (2B) | SD | 28 | |
| Vinnie Pasquantino | 1B | KC | 28 | |
| Brendan Donovan | 2B (SS,OF) | StL | 28 | |
| Bryson Stott | 2B (SS) | Phi | 28 | |
| CJ Abrams | SS | Was | 25 | |
| Javier Baez | SS (2B,3B,OF) | Det | 32 | |
| Jose Caballero | SS (2B,3B,OF) | NYA | 29 | |
| Casey Schmitt | SS (1B,2B,3B) | SF | 26 | |
| Bobby Witt Jr. | SS | KC | 25 | |
| Junior Caminero | 3B | TB | 22 | |
| Austin Riley | 3B | Atl | 28 | August 04, 2025:60 Day IL |
| Corbin Carroll | OF | Ari | 25 | |
| Colton Cowser | OF | Bal | 25 | |
| Riley Greene | OF | Det | 25 | |
| Ramón Laureano | OF | SD | 31 | September 27, 2025:10 Day IL |
| Luis Robert Jr. | OF | ChA | 28 | August 27, 2025:10 Day IL |
| Daulton Varsho | OF | Tor | 29 | |
| Chris Bassitt | SP | Tor | 36 | September 20, 2025:15 Day IL |
| Brayan Bello | SP | Bos | 26 | |
| Nathan Eovaldi | SP | Tex | 35 | August 27, 2025:15 Day IL |
| Sonny Gray | SP | StL | 35 | |
| Michael King | SP | SD | 30 | |
| Ryan Pepiot | SP | TB | 28 | |
| Nick Pivetta | SP | SD | 32 | |
| Drew Rasmussen | SP | TB | 30 | |
| Trevor Rogers | SP | Bal | 27 | |
| Brady Singer | SP | Cin | 29 | |
| José Soriano | SP | LAA | 27 | September 18, 2025:15 Day IL |
| Spencer Strider | SP | Atl | 26 | |
| David Bednar | RP | NYA | 31 | |
| Jhoan Duran | RP | Phi | 27 |