| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Francisco Álvarez | C | NYN | 23 | |
| Miguel Amaya | C | ChN | 26 | May 25, 2025:10 Day IL-Left oblique strain |
| Tyler Stephenson | C | Cin | 28 | |
| Bryce Harper | 1B | Phi | 32 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Andrés Gimenez | 2B | Tor | 26 | |
| Nick Gonzales | 2B | Pit | 26 | |
| Willy Adames | SS | SF | 29 | |
| Amed Rosario | SS (2B,3B) | Was | 29 | |
| Alec Bohm | 3B (1B) | Phi | 28 | |
| Maikel Garcia | 3B (2B,SS,OF) | KC | 25 | |
| Alec Burleson | OF (1B) | StL | 26 | |
| Colton Cowser | OF | Bal | 25 | |
| Jarren Duran | OF | Bos | 28 | |
| Aaron Judge | OF | NYA | 33 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Wenceel Perez | OF | Det | N/A | |
| Brent Rooker | OF | Oak | 30 | |
| Anthony Santander | OF | Tor | 30 | May 30, 2025:10 Day IL |
| Mike Trout | OF | LAA | 33 | |
| Luis Castillo | SP | Sea | 32 | |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| Yu Darvish | SP | SD | 38 | March 27, 2025:60 Day IL |
| Yusei Kikuchi | SP | LAA | 34 | |
| Jesus Luzardo | SP | Phi | 27 | |
| Frankie Montas | SP | NYN | 32 | |
| David Peterson | SP | NYN | 29 | |
| Carlos Rodon | SP | NYA | 32 | |
| Joe Ryan | SP | Min | 29 | |
| Chris Sale | SP | Atl | 36 | June 21, 2025:60 Day IL |
| Max Scherzer | SP | Tor | 40 | |
| Kodai Senga | SP | NYN | 32 | June 13, 2025:15 Day IL |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Randy Vasquez | SP | SD | 26 |