| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Carlos Narvaez | C | Bos | 26 | |
| Cal Raleigh | C | Sea | 28 | |
| Michael Busch | 1B | ChN | 27 | |
| Willson Contreras | 1B | StL | 33 | September 17, 2025:10 Day IL |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Jose Altuve | 2B (OF) | Hou | 35 | |
| Romy Gonzalez | 2B (1B) | Bos | 29 | |
| Zach McKinstry | 2B (SS,3B,OF) | Det | 30 | |
| Jose Caballero | SS (2B,3B,OF) | NYA | 29 | |
| Carlos Correa | SS (3B) | Hou | 31 | |
| Gunnar Henderson | SS | Bal | 24 | |
| Manny Machado | 3B | SD | 33 | |
| Noelvi Marte | 3B (OF) | Cin | 23 | |
| Yoan Moncada | 3B | LAA | 30 | |
| Ramón Laureano | OF | SD | 31 | September 27, 2025:10 Day IL |
| Luis Robert Jr. | OF | ChA | 28 | August 27, 2025:10 Day IL |
| Shane Bieber | SP | Tor | 30 | |
| Matt Boyd | SP | ChN | 34 | |
| Luis Castillo | SP | Sea | 32 | |
| Hunter Greene | SP | Cin | 26 | |
| Zack Littell | SP | Cin | 30 | |
| Tyler Mahle | SP | Tex | 31 | |
| David Peterson | SP | NYN | 30 | |
| Jose Quintana | SP | Mil | 36 | September 17, 2025:15 Day IL |
| José Soriano | SP | LAA | 26 | September 18, 2025:15 Day IL |
| Yoshinobu Yamamoto | SP | LAD | 27 | |
| Trey Yesavage | SP | Tor | 22 | |
| Pete Fairbanks | RP | TB | 31 | |
| Robert Garcia | RP | Tex | N/A | |
| Daniel Palencia | RP | ChN | N/A | |
| Robert Suarez | RP | SD | 34 | |
| Will Vest | RP | Det | 30 |