| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Dillon Dingler | C | Det | N/A | |
| Christian Encarnacion-Strand | 1B (3B) | Cin | 25 | |
| Jonathon Long | 1B | ChN | 23 | |
| Kyle Manzardo | 1B | Cle | 24 | |
| Carlos Santana | 1B | Cle | 39 | |
| Michael Toglia | 1B | Col | 26 | |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:60 Day IL |
| Brice Matthews | 2B | Hou | 23 | |
| Jeff McNeil | 2B (OF) | NYN | 33 | |
| Christian Moore | 2B | LAA | 22 | |
| Casey Schmitt | SS (1B,3B) | SF | 26 | |
| Ezequiel Tovar | SS | Col | 23 | June 06, 2025:10 Day IL |
| Jett Williams | SS | NYN | 21 | |
| Royce Lewis | 3B | Min | 26 | June 14, 2025:10 Day IL |
| Matt Shaw | 3B | ChN | 23 | |
| Abraham Toro | 3B (1B) | Bos | 28 | |
| Jo Adell | OF | LAA | 26 | |
| Roman Anthony | OF | Bos | 21 | |
| Lawrence Butler | OF | Oak | 24 | |
| Dylan Crews | OF | Was | 23 | May 21, 2025:10 Day IL |
| Trent Grisham | OF | NYA | 28 | |
| Jesus Sanchez | OF | Mia | 27 | |
| Seiya Suzuki | OF | ChN | 30 | |
| Chase Burns | SP | Cin | 22 | |
| Pat Corbin | SP | Tex | 35 | |
| Zac Gallen | SP | Ari | 29 | |
| Reese Olson | SP | Det | 25 | May 19, 2025:15 Day IL |
| Brandon Pfaadt | SP | Ari | 26 | |
| Luis Severino | SP | Oak | 31 | |
| Tarik Skubal | SP | Det | 28 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:60 Day IL-Ab strain |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Michael Wacha | SP | KC | 34 | |
| Yoshinobu Yamamoto | SP | LAD | 26 |