| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Samuel Basallo | C | Bal | 20 | |
| Carson Kelly | C | ChN | 30 | |
| Shea Langeliers | C | Oak | 27 | |
| Triston Casas | 1B | Bos | 25 | May 03, 2025:60 Day IL |
| Deyvison De Los Santos | 1B | Mia | 22 | |
| C.J. Kayfus | 1B | Cle | 23 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Bryson Stott | 2B | Phi | 27 | |
| Carlos Correa | SS | Min | 30 | |
| Max Muncy | SS (2B,3B) | Oak | 22 | |
| Trea Turner | SS | Phi | 32 | |
| Jett Williams | SS | NYN | 21 | |
| Alex Bregman | 3B | Bos | 31 | May 24, 2025:10 Day IL |
| Kerry Carpenter | OF | Det | 27 | July 01, 2025:10 Day IL |
| Adolis Garcia | OF | Tex | 32 | |
| Michael Harris II | OF | Atl | 24 | |
| Austin Hays | OF | Cin | 30 | |
| Josh Lowe | OF | TB | 27 | |
| Mickey Moniak | OF | Col | 27 | |
| Tyler O'Neill | OF | Bal | 30 | |
| Jesus Sanchez | OF | Mia | 27 | |
| James Wood | OF | Was | 22 | |
| Mick Abel | SP | Phi | N/A | |
| Taj Bradley | SP | TB | 24 | |
| Lucas Giolito | SP | Bos | 30 | |
| Dustin May | SP | LAD | 27 | |
| Lance McCullers | SP | Hou | 31 | |
| Bryce Miller | SP | Sea | 26 | June 10, 2025:15 Day IL-Right elbow inflammation |
| Cole Ragans | SP | KC | 27 | June 11, 2025:15 Day IL |
| Chris Sale | SP | Atl | 36 | June 21, 2025:60 Day IL |
| Jameson Taillon | SP | ChN | 33 | July 04, 2025:15 Day IL |
| Shelby Miller | RP | Ari | 34 | |
| Ryne Nelson | RP (SP) | Ari | 27 | |
| Emilio Pagan | RP | Cin | 34 |