| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Salvador Perez | C (C,1B) | KC | 35 | |
| Tyler Stephenson | C | Cin | 28 | |
| Nathaniel Lowe | 1B | Was | 29 | |
| Josh Naylor | 1B | Ari | 28 | |
| Carlos Santana | 1B | Cle | 39 | |
| Jose Altuve | 2B (OF) | Hou | 35 | |
| Brendan Donovan | 2B (SS,OF) | StL | 28 | |
| Wilmer Flores | 2B (1B) | SF | 33 | |
| Xavier Edwards | SS (2B) | Mia | 25 | |
| Dansby Swanson | SS | ChN | 31 | |
| Nolan Arenado | 3B | StL | 34 | |
| Matt Chapman | 3B | SF | 32 | June 10, 2025:10 Day IL |
| Isaac Paredes | 3B | Hou | 26 | |
| Sal Frelick | OF | Mil | 25 | |
| Teoscar Hernández | OF | LAD | 32 | |
| Andrew McCutchen | OF | Pit | 38 | |
| Anthony Santander | OF | Tor | 30 | May 30, 2025:10 Day IL |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Mike Trout | OF | LAA | 33 | |
| Taylor Ward | OF | LAA | 31 | |
| Marcell Ozuna | DH | Atl | 34 | |
| Nathan Eovaldi | SP | Tex | 35 | |
| Jake Irvin | SP | Was | 28 | |
| Merrill Kelly | SP | Ari | 36 | |
| Seth Lugo | SP | KC | 35 | |
| Ryan Pepiot | SP | TB | 27 | |
| Brady Singer | SP | Cin | 28 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:60 Day IL-Ab strain |
| Jeffrey Springs | SP | Oak | 32 | |
| Michael Wacha | SP | KC | 34 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Pete Fairbanks | RP | TB | 31 | |
| Emilio Pagan | RP | Cin | 34 |