| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Kyle Farmer | C (1B,2B,3B,SS) | Cin | 31 | |
| Keibert Ruiz | C | Was | 23 | |
| Daulton Varsho | C (OF) | Ari | 25 | |
| Bobby Bradley | 1B (DH) | Cle | 25 | |
| Gavin Sheets | 1B (OF,DH) | ChA | 25 | |
| Jared Walsh | 1B (OF) | LAA | 28 | |
| Ketel Marte | 2B (OF) | Ari | 27 | |
| Jazz Chisholm | SS (2B) | Mia | 23 | |
| Francisco Lindor | SS | NYN | 27 | |
| Marco Luciano | SS | SF | 20 | |
| Alec Bohm | 3B (1B) | Phi | 25 | |
| Nolan Gorman | 3B | StL | 21 | |
| Anthony Rendon | 3B | LAA | 31 | July 05, 2021:10 Day IL-Strained left hamstring |
| Randy Arozarena | OF (DH) | TB | 26 | |
| Harrison Bader | OF | StL | 27 | |
| Mark Canha | OF (DH) | Oak | 32 | |
| Riley Greene | OF | Det | 20 | |
| Eloy Jimenez | OF (DH) | ChA | 24 | |
| Pedro Leon | OF | Hou | 23 | |
| Josh Lowe | OF | TB | 23 | |
| Chas McCormick | OF | Hou | 26 | |
| Wil Myers | OF | SD | 30 | |
| Anthony Santander | OF (DH) | Bal | 26 | |
| J.D. Martinez | DH (OF) | Bos | 34 | |
| Mike Clevinger | SP | SD | 30 | February 18, 2021:60 Day IL-Recovery from right elbow surgery |
| Pat Corbin | SP | Was | 32 | |
| Josh Fleming | SP (RP) | TB | 26 | |
| Chris Flexen | SP | Sea | 27 | |
| Logan Gilbert | SP | Sea | 24 | |
| Lucas Giolito | SP | ChA | 27 | |
| Marco Gonzales | SP | Sea | 29 | |
| Alek Manoah | SP | Tor | 23 | |
| Chris Sale | SP | Bos | 32 | |
| Stephen Strasburg | SP | Was | 33 | June 02, 2021:10 Day IL-Neck strain |