| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Francisco Álvarez | C | NYN | 23 | |
| Sean Murphy | C | Atl | 31 | September 08, 2025:60 Day IL |
| Dalton Rushing | C (C,1B) | LAD | 24 | |
| Bryce Eldridge | 1B | SF | 21 | |
| Jonathon Long | 1B | ChN | 23 | |
| Gunnar Henderson | SS | Bal | 24 | |
| Max Muncy | SS (2B,3B) | Oak | 23 | |
| JJ Wetherholt | SS | StL | 23 | |
| Carson Williams | SS | TB | 22 | |
| Brady House | 3B | Was | 22 | |
| Josh Jung | 3B | Tex | 27 | |
| Kyle Karros | 3B | Col | 23 | |
| Matt Shaw | 3B | ChN | 23 | |
| Mark Vientos | 3B | NYN | 25 | |
| Dylan Beavers | OF | Bal | N/A | |
| Carson Benge | OF | NYN | 22 | |
| Charlie Condon | OF | Col | 22 | |
| Colton Cowser | OF | Bal | 25 | |
| Drew Gilbert | OF | SF | 25 | |
| Trent Grisham | OF | NYA | 28 | |
| Michael Harris II | OF | Atl | 24 | |
| Mickey Moniak | OF | Col | 27 | |
| Andy Pages | OF | LAD | 24 | |
| Kyle Stowers | OF | Mia | 27 | August 17, 2025:10 Day IL |
| Jose Berrios | SP | Tor | 31 | September 25, 2025:15 Day IL |
| Slade Cecconi | SP | Cle | 26 | |
| Max Fried | SP | NYA | 31 | |
| Aaron Nola | SP | Phi | 32 | |
| Grayson Rodriguez | SP | Bal | 25 | March 27, 2025:60 Day IL |
| Emmet Sheehan | SP (RP) | LAD | 25 | |
| Blake Snell | SP | LAD | 32 | |
| Robby Snelling | SP | Mia | 21 | |
| Jonah Tong | SP | NYN | 22 | |
| Gavin Williams | SP | Cle | 26 |