| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Sean Murphy | C | Atl | 30 | |
| Jonathan Aranda | 1B | TB | 27 | |
| Bryce Eldridge | 1B | SF | 20 | |
| Christian Encarnacion-Strand | 1B (3B) | Cin | 25 | |
| Jonathon Long | 1B | ChN | 23 | |
| Gunnar Henderson | SS | Bal | 24 | |
| Ronny Mauricio | SS (2B,3B) | NYN | 24 | |
| Max Muncy | SS (2B,3B) | Oak | 22 | |
| Ryan Ritter | SS | Col | 24 | |
| Trevor Story | SS | Bos | 32 | |
| Carson Williams | SS | TB | 22 | |
| Brady House | 3B | Was | 22 | |
| Josh Jung | 3B | Tex | 27 | |
| Charlie Condon | OF | Col | 22 | |
| Colton Cowser | OF | Bal | 25 | |
| Adolis Garcia | OF | Tex | 32 | |
| Trent Grisham | OF | NYA | 28 | |
| Michael Harris II | OF | Atl | 24 | |
| Tyler O'Neill | OF | Bal | 30 | May 18, 2025:10 Day IL |
| Andy Pages | OF | LAD | 24 | |
| Kyle Stowers | OF | Mia | 27 | |
| Mick Abel | SP | Phi | N/A | |
| Jose Berrios | SP | Tor | 31 | |
| Aaron Civale | SP | ChA | 30 | |
| Pat Corbin | SP | Tex | 35 | |
| Max Fried | SP | NYA | 31 | |
| Lucas Giolito | SP | Bos | 30 | |
| Dustin May | SP | LAD | 27 | |
| Aaron Nola | SP | Phi | 32 | May 16, 2025:60 Day IL |
| Jack Perkins | SP | Oak | N/A | |
| Kumar Rocker | SP | Tex | N/A | |
| Grayson Rodriguez | SP | Bal | 25 | March 27, 2025:60 Day IL |
| Emmet Sheehan | SP | LAD | 25 | |
| Gavin Williams | SP | Cle | 25 |