| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Adley Rutschman | C | Bal | 27 | |
| Austin Wells | C | NYA | 26 | |
| Yandy Diaz | 1B | TB | 34 | |
| Paul Goldschmidt | 1B | NYA | 38 | |
| Zach McKinstry | 2B (SS,3B,OF) | Det | 30 | |
| Marcus Semien | 2B | Tex | 35 | August 23, 2025:60 Day IL |
| Brice Turang | 2B | Mil | 25 | |
| Javier Baez | SS (2B,3B,OF) | Det | 32 | |
| Carlos Correa | SS (3B) | Hou | 31 | |
| Geraldo Perdomo | SS | Ari | 26 | |
| Yoan Moncada | 3B | LAA | 30 | |
| Austin Riley | 3B | Atl | 28 | August 04, 2025:60 Day IL |
| Josh Smith | 3B (1B,SS,OF) | Tex | 28 | |
| Brenton Doyle | OF | Col | 27 | |
| Jarren Duran | OF | Bos | 29 | |
| Andrew McCutchen | OF | Pit | 39 | |
| Anthony Santander | OF | Tor | 31 | |
| Spencer Steer | OF (1B) | Cin | 27 | |
| Kyle Stowers | OF | Mia | 27 | August 17, 2025:10 Day IL |
| Marcell Ozuna | DH | Atl | 34 | |
| Tyler Bremner | SP | LAA | 21 | |
| Liam Doyle | SP | StL | 21 | |
| Adrian Houser | SP | TB | 32 | |
| Mitch Keller | SP | Pit | 29 | |
| Merrill Kelly | SP | Tex | 37 | |
| Seth Lugo | SP | KC | 35 | September 04, 2025:15 Day IL |
| Dustin May | SP | Bos | 28 | September 09, 2025:15 Day IL |
| Bryce Miller | SP | Sea | 27 | |
| Carlos Rodon | SP | NYA | 32 | |
| Brady Singer | SP | Cin | 29 | |
| Yoshinobu Yamamoto | SP | LAD | 27 | |
| Kyle Finnegan | RP | Det | 34 | |
| Trevor Megill | RP | Mil | 31 | August 27, 2025:15 Day IL |
| Robert Suarez | RP | SD | 34 |