| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| J.T. Realmuto | C | Phi | 34 | |
| Jonathan Aranda | 1B | TB | 27 | August 01, 2025:10 Day IL |
| Jake Burger | 1B | Tex | 29 | |
| Willson Contreras | 1B | StL | 33 | September 17, 2025:10 Day IL |
| Ozzie Albies | 2B | Atl | 28 | |
| Daniel Schneemann | 2B (SS,3B,OF) | Cle | 28 | |
| Ronny Mauricio | SS (2B,3B) | NYN | 24 | |
| Trea Turner | SS | Phi | 32 | September 08, 2025:10 Day IL |
| Ernie Clement | 3B (1B,2B,SS) | Tor | 29 | |
| Manny Machado | 3B | SD | 33 | |
| Max Muncy | 3B | LAD | 35 | |
| Mark Vientos | 3B | NYN | 25 | |
| Jo Adell | OF | LAA | 26 | |
| Corbin Carroll | OF | Ari | 25 | |
| Drew Gilbert | OF | SF | 24 | |
| Trent Grisham | OF | NYA | 28 | |
| Ramón Laureano | OF | SD | 31 | |
| Jakob Marsee | OF | Mia | N/A | |
| Luis Matos | OF | SF | 23 | |
| Lars Nootbaar | OF | StL | 28 | |
| Luis Robert Jr. | OF | ChA | 28 | August 27, 2025:10 Day IL |
| Jesus Sanchez | OF | Hou | 27 | |
| Mike Trout | OF | LAA | 34 | |
| Chris Bassitt | SP | Tor | 36 | |
| Shane Baz | SP | TB | 26 | |
| Aaron Civale | SP (RP) | ChN | 30 | |
| Kevin Gausman | SP | Tor | 34 | |
| Matthew Liberatore | SP | StL | 25 | |
| Quinn Priester | SP (RP) | Mil | 25 | |
| Drew Rasmussen | SP | TB | 30 | |
| Chris Sale | SP | Atl | 36 | |
| Kodai Senga | SP | NYN | 32 | |
| Ranger Suarez | SP | Phi | 30 | |
| Bryan Woo | SP | Sea | 25 |