| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Miguel Amaya | C | ChN | 26 | May 25, 2025:10 Day IL-Left oblique strain |
| Adley Rutschman | C | Bal | 27 | June 21, 2025:10 Day IL |
| Willson Contreras | 1B | StL | 33 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Travis Bazzana | 2B | Cle | 22 | |
| Jake Cronenworth | 2B (1B) | SD | 31 | |
| Nolan Gorman | 2B (3B) | StL | 25 | |
| Xavier Edwards | SS (2B) | Mia | 25 | |
| Jeremy Pena | SS | Hou | 27 | June 30, 2025:15 Day IL-Rib |
| Ezequiel Tovar | SS | Col | 23 | June 06, 2025:10 Day IL |
| Austin Riley | 3B | Atl | 28 | |
| Byron Buxton | OF | Min | 31 | |
| Charlie Condon | OF | Col | 22 | |
| Michael Conforto | OF | LAD | 32 | |
| Ian Happ | OF | ChN | 30 | |
| Heliot Ramos | OF | SF | 25 | |
| George Springer | OF | Tor | 35 | |
| Seiya Suzuki | OF | ChN | 30 | |
| James Wood | OF | Was | 22 | |
| Yu Darvish | SP | SD | 38 | March 27, 2025:60 Day IL |
| Jacob deGrom | SP | Tex | 37 | |
| Jordan Hicks | SP (RP) | Bos | 28 | |
| Mitch Keller | SP | Pit | 29 | |
| Sean Manaea | SP | NYN | 33 | March 27, 2025:60 Day IL |
| Quinn Mathews | SP | StL | N/A | |
| Mitchell Parker | SP | Was | 25 | |
| David Peterson | SP | NYN | 29 | |
| Colin Rea | SP (RP) | ChN | 34 | |
| Cristopher Sanchez | SP | Phi | 28 | |
| David Bednar | RP | Pit | 30 | |
| Camilo Doval | RP | SF | 27 | |
| Ryan Pressly | RP | ChN | 36 | |
| AJ Puk | RP | Ari | 30 | April 19, 2025:60 Day IL-Left elbow inflammation |