| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yermín Mercedes | C (DH) | ChA | 28 | |
| Luis Torrens | C (1B,DH) | Sea | 25 | |
| Triston Casas | 1B | Bos | 21 | |
| C.J. Cron | 1B (DH) | Col | 31 | |
| Nate Lowe | 1B (DH) | Tex | 26 | |
| Keston Hiura | 2B (1B) | Mil | 25 | |
| Jonathan India | 2B | Cin | 24 | |
| Zach McKinstry | 2B (3B,OF) | LAD | 26 | |
| Mike Moustakas | 2B (1B,3B) | Cin | 33 | September 21, 2021:10 Day IL-Right foot plantar fasciitis |
| Brendan Rodgers | 2B (SS) | Col | 25 | |
| Dansby Swanson | SS | Atl | 27 | |
| Miguel Andújar | 3B (OF) | NYA | 26 | July 07, 2021:10 Day IL-Strained left wrist |
| Yandy Diaz | 3B (1B,DH) | TB | 30 | |
| Colin Moran | 3B (1B,DH) | Pit | 28 | |
| Eugenio Suarez | 3B (SS) | Cin | 30 | |
| Jo Adell | OF | LAA | 22 | September 12, 2021:10 Day IL-Left abdominal strain |
| Andrew Benintendi | OF | KC | 27 | |
| Charlie Blackmon | OF | Col | 35 | |
| Austin Hays | OF | Bal | 26 | |
| Teoscar Hernández | OF (DH) | Tor | 28 | |
| Kyle Schwarber | OF (1B,DH) | Bos | 28 | |
| Raimel Tapia | OF | Col | 27 | |
| Mike Trout | OF | LAA | 30 | May 18, 2021:10 Day IL-Strained right calf - out 6-8 weeks |
| LaMonte Wade Jr | OF (1B) | SF | 27 | |
| Mike Clevinger | SP | SD | 30 | February 18, 2021:60 Day IL-Recovery from right elbow surgery |
| MacKenzie Gore | SP | SD | 22 | |
| Shane McClanahan | SP | TB | 24 | |
| Triston McKenzie | SP | Cle | 24 | |
| Wily Peralta | SP | Det | 32 | |
| Eduardo Rodriguez | SP | Bos | 28 | |
| Jameson Taillon | SP | NYA | 29 | September 07, 2021:10 Day IL-Right ankle tendon injury |
| Logan Webb | SP | SF | 24 | |
| Austin Gomber | RP (SP) | Col | 27 | September 04, 2021:10 Day IL-Stress fracture, lower back |
| Will Smith | RP | Atl | 32 |