| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Jonah Heim | C | Tex | 30 | |
| Cal Raleigh | C | Sea | 28 | |
| Ty France | 1B | Min | 30 | |
| Rhys Hoskins | 1B | Mil | 32 | |
| Tyler Fitzgerald | 2B | SF | 27 | |
| Zach McKinstry | 2B (SS,3B,OF) | Det | 30 | |
| Gleyber Torres | 2B | Det | 28 | |
| J.P. Crawford | SS | Sea | 30 | |
| Francisco Lindor | SS | NYN | 31 | |
| Manny Machado | 3B | SD | 32 | |
| Ryan McMahon | 3B | Col | 30 | |
| JJ Bleday | OF | Oak | 27 | |
| Oneil Cruz | OF | Pit | 26 | |
| Ian Happ | OF | ChN | 30 | |
| Trevor Larnach | OF | Min | 28 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Jurickson Profar | OF | Atl | 32 | |
| Luke Raley | OF (1B) | Sea | 30 | |
| Anthony Santander | OF | Tor | 30 | May 30, 2025:10 Day IL |
| Gavin Sheets | OF (1B) | SD | 29 | |
| Chris Bassitt | SP | Tor | 36 | |
| Bailey Falter | SP | Pit | 28 | |
| Max Fried | SP | NYA | 31 | |
| Jake Irvin | SP | Was | 28 | |
| Bryce Miller | SP | Sea | 26 | June 10, 2025:15 Day IL-Right elbow inflammation |
| David Peterson | SP | NYN | 29 | |
| Carlos Rodon | SP | NYA | 32 | |
| JP Sears | SP | Oak | 29 | |
| Ranger Suarez | SP | Phi | 29 | |
| Logan Webb | SP | SF | 28 | |
| Camilo Doval | RP | SF | 28 | |
| Kyle Finnegan | RP | Was | 33 | |
| Tanner Scott | RP | LAD | 30 |