| Rank | Score | Team | Week | Owner(s) |
| 1. | 444 | Antibiotics | Week 17, 2005 | Marc Fazzio |
| 2. | 391 | Antibiotics | Week 3, 2005 | Marc Fazzio |
| 3. | 384 | Antibiotics | Week 8, 2005 | Marc Fazzio |
| 4. | 372 | Antibiotics | Week 13, 2005 | Marc Fazzio |
| 5. | 364 | Antibiotics | Week 16, 2005 | Marc Fazzio |
| 6. | 350 | Antibiotics | Week 18, 2005 | Marc Fazzio |
| 7. | 342 | Antibiotics | Week 19, 2005 | Marc Fazzio |
| 8. | 340 | Antibiotics | Week 9, 2005 | Marc Fazzio |
| 9. | 338 | Antibiotics | Week 12, 2005 | Marc Fazzio |
| 10. | 336 | Antibiotics | Week 11, 2005 | Marc Fazzio |
| 11. | 334 | Antibiotics | Week 10, 2005 | Marc Fazzio |
| 12. | 317 | Antibiotics | Week 14, 2005 | Marc Fazzio |
| 12. | 317 | Antibiotics | Week 4, 2005 | Marc Fazzio |
| 14. | 303 | Antibiotics | Week 7, 2005 | Marc Fazzio |
| 15. | 302 | Antibiotics | Week 2, 2005 | Marc Fazzio |
| 16. | 296 | Antibiotics | Week 6, 2005 | Marc Fazzio |
| 17. | 294 | Antibiotics | Week 1, 2005 | Marc Fazzio |