| Round | Overall | Player |
|---|---|---|
| 1 | 12th | 3B David Wright NYN |
| 2 | 13th | 3B Miguel Cabrera Fla |
| 3 | 36th | OF Adam Dunn Cin |
| 4 | 37th | SS Jose Reyes NYN |
| 5 | 60th | 2B Marcus Giles Atl |
| 6 | 61st | SP Felix Hernandez Sea |
| 7 | 84th | SP Mark Buehrle ChA |
| 8 | 85th | OF Pat Burrell Phi |
| 9 | 108th | SS Bobby Crosby Oak |
| 10 | 109th | SP Mark Mulder StL |
| 11 | 132nd | DH Javy Lopez Bos |
| 12 | 133rd | SP Javier Vazquez ChA |
| 13 | 156th | RP Bobby Jenks ChA |
| 14 | 157th | SS Clint Barmes Col |
| 15 | 180th | OF Austin Kearns Was |
| 16 | 181st | 3B Edwin Encarnacion Cin |
| 17 | 204th | OF Shawn Green NYN |
| 18 | 205th | SP Francisco Liriano Min |
| 19 | 228th | OF Josh Willingham Fla |
| 20 | 229th | OF Curtis Granderson Det |
| 21 | 252nd | SP Daniel Cabrera Bal |
| 22 | 253rd | 1B Nick Johnson Was |
| 23 | 276th | RP Jose Valverde Ari |
| 24 | 277th | 1B Sean Casey Det |
| 25 | 300th | RP Mike Gonzalez Atl |
| 26 | 301st | OF Nick Markakis Bal |
| 27 | 324th | OF Jason Kubel Min |
| 28 | 325th | 3B Andy Marte Cle |
| 29 | 348th | OF Corey Patterson Bal |