| Round | Overall | Player |
|---|---|---|
| 1 | 6th | 2B Chase Utley Phi |
| 2 | 19th | SP Johan Santana NYN |
| 3 | 30th | SP Brandon Webb Ari |
| 4 | 43rd | SP Justin Verlander Det |
| 5 | 54th | OF Nick Swisher ChA |
| 6 | 67th | RP J.J. Putz Sea |
| 7 | 78th | OF Brad Hawpe Col |
| 8 | 91st | RP Bobby Jenks ChA |
| 9 | 102nd | OF Jason Bay Bos |
| 10 | 115th | 1B Carlos Guillen Det |
| 11 | 126th | 3B Alex Gordon KC |
| 12 | 139th | SP Jered Weaver LAA |
| 13 | 150th | 1B Kevin Youkilis Bos |
| 14 | 163rd | SS Yunel Escobar Atl |
| 15 | 174th | 3B Edwin Encarnacion Cin |
| 16 | 187th | SS Julio Lugo Bos |
| 17 | 198th | OF Luke Scott Bal |
| 18 | 211th | 3B Evan Longoria TB |
| 19 | 222nd | OF Melky Cabrera NYA |
| 20 | 235th | SP Edison Volquez Cin |
| 21 | 246th | C Carlos Ruiz Phi |
| 22 | 259th | SP Carlos Villanueva Mil |
| 23 | 270th | OF Mark Teahen KC |
| 24 | 283rd | 1B Jarrod Saltalamacchia Tex |
| 25 | 294th | SP Daniel Cabrera Bal |
| 26 | 307th | C Gerald Laird Tex |
| 27 | 318th | SP Dustin Moseley LAA |
| 28 | 331st | 1B Ben Broussard Tex |
| 29 | 342nd | 2B Jayson Nix Col |