| Round | Overall | Player |
|---|---|---|
| 1 | 1st | SS Hanley Ramirez Fla |
| 2 | 24th | SP C.C. Sabathia NYA |
| 3 | 25th | OF Matt Holliday StL |
| 4 | 48th | DH Vladimir Guerrero Tex |
| 5 | 49th | 1B Adam Dunn Was |
| 6 | 72nd | 1B Chris Davis Tex |
| 7 | 73rd | SP Cliff Lee Sea |
| 8 | 96th | C Chris Iannetta Col |
| 9 | 97th | 3B Alex Gordon KC |
| 10 | 120th | 2B Rickie Weeks Mil |
| 11 | 121st | OF J.D. Drew Bos |
| 12 | 144th | OF Mark DeRosa SF |
| 13 | 145th | DH Hideki Matsui LAA |
| 14 | 168th | SP Gavin Floyd ChA |
| 15 | 169th | SP Andy Pettitte NYA |
| 16 | 192nd | RP Matt Lindstrom Hou |
| 17 | 193rd | C Matt Wieters Bal |
| 18 | 216th | RP Trevor Hoffman Mil |
| 19 | 217th | RP Huston Street Col |
| 20 | 240th | SP Jesse Litsch Tor |
| 21 | 241st | 1B Jason Giambi Col |
| 22 | 264th | SP Kyle Lohse StL |
| 23 | 265th | SP Bronson Arroyo Cin |
| 24 | 288th | OF Ryan Spilborghs Col |
| 25 | 289th | SS Khalil Greene Tex |
| 26 | 312th | 3B Josh Fields KC |
| 27 | 313th | SP Anthony Reyes Cle |
| 28 | 336th | SP Edwin Jackson Ari |
| 29 | 337th | SP Nick Blackburn Min |