| Round | Overall | Player |
|---|---|---|
| 1 | 10th | 2B Chase Utley Phi |
| 2 | 15th | 3B Evan Longoria TB |
| 3 | 34th | 1B Kevin Youkilis Bos |
| 4 | 39th | DH David Ortiz Bos |
| 5 | 58th | RP Jon Papelbon Bos |
| 6 | 63rd | RP Mariano Rivera NYA |
| 7 | 82nd | SS Stephen Drew Ari |
| 8 | 87th | SP A.J. Burnett NYA |
| 9 | 106th | OF Jermaine Dye ChA |
| 10 | 111th | SP Joba Chamberlain NYA |
| 11 | 130th | SP David Price TB |
| 12 | 135th | OF Cameron Maybin Fla |
| 13 | 154th | OF Rick Ankiel KC |
| 14 | 159th | SP Johnny Cueto Cin |
| 15 | 178th | OF Shane Victorino Phi |
| 16 | 183rd | SP Chris Volstad Fla |
| 17 | 202nd | RP Brian Wilson SF |
| 18 | 207th | OF Delmon Young Min |
| 19 | 226th | SP Brad Penny StL |
| 20 | 231st | C Jarrod Saltalamacchia Tex |
| 21 | 250th | SP Tommy Hanson Atl |
| 22 | 255th | C Ivan Rodriguez Hou |
| 23 | 274th | SP Jordan Zimmermann Was |
| 24 | 279th | 1B Ty Wigginton Bal |
| 25 | 298th | SP Sean Gallagher ChN |
| 26 | 303rd | 1B Kevin Millar Tor |
| 27 | 322nd | SS Asdrubal Cabrera Cle |
| 28 | 327th | SS Jason Bartlett TB |
| 29 | 346th | C Max Ramirez Tex |