| Round | Overall | Player |
|---|---|---|
| 1 | 3rd | 1B Albert Pujols StL |
| 2 | 22nd | 2B Dustin Pedroia Bos |
| 3 | 27th | 3B Evan Longoria TB |
| 4 | 46th | OF Curtis Granderson NYA |
| 5 | 51st | RP Jon Papelbon Bos |
| 6 | 70th | SP James Shields TB |
| 7 | 75th | OF Hunter Pence Hou |
| 8 | 94th | SS J.J. Hardy Min |
| 9 | 99th | OF Jay Bruce Cin |
| 10 | 118th | 3B Pablo Sandoval SF |
| 11 | 123rd | SP Kevin Slowey Min |
| 12 | 142nd | OF Torii Hunter LAA |
| 13 | 147th | SP Brett Myers Hou |
| 14 | 166th | 1B Aubrey Huff SF |
| 15 | 171st | SP Roberto Hernandez Cle |
| 16 | 190th | SP Gil Meche KC |
| 17 | 195th | SP Jered Weaver LAA |
| 18 | 214th | RP Trevor Hoffman Mil |
| 19 | 219th | SP Andy Pettitte NYA |
| 20 | 238th | SP Manny Parra Mil |
| 21 | 243rd | SS Edgar Renteria SF |
| 22 | 262nd | 2B Felipe Lopez Mil |
| 23 | 267th | C Kurt Suzuki Oak |
| 24 | 286th | OF David DeJesus KC |
| 25 | 291st | 3B Casey Blake LAD |
| 26 | 310th | 1B Ty Wigginton Bal |
| 27 | 315th | OF Jose Guillen KC |
| 28 | 334th | SP Kevin Millwood Tex |
| 29 | 339th | DH Jason Kubel Min |