| Round | Overall | Player |
|---|---|---|
| 1 | 4th | C Joe Mauer Min |
| 2 | 21st | 2B Ian Kinsler Tex |
| 3 | 28th | OF Nelson Cruz Tex |
| 4 | 45th | 1B Adam Dunn ChA |
| 5 | 52nd | RP Jon Papelbon Bos |
| 6 | 69th | RP Mariano Rivera NYA |
| 7 | 76th | SP Cole Hamels Phi |
| 8 | 93rd | RP Joakim Soria KC |
| 9 | 100th | 2B Howie Kendrick LAA |
| 10 | 117th | OF Bobby Abreu LAA |
| 11 | 124th | 3B Chipper Jones Atl |
| 12 | 141st | SP Kevin Slowey Min |
| 13 | 148th | SP Clay Buchholz Bos |
| 14 | 165th | 1B Chris Davis Tex |
| 15 | 172nd | DH Vladimir Guerrero Tex |
| 16 | 189th | SP Brian Matusz Bal |
| 17 | 196th | SP Philip Hughes NYA |
| 18 | 213th | OF J.D. Drew Bos |
| 19 | 220th | SS Erick Aybar LAA |
| 20 | 237th | OF Kyle Blanks SD |
| 21 | 244th | SS Alcides Escobar KC |
| 22 | 261st | 3B Scott Rolen Cin |
| 23 | 268th | SP Ian Kennedy Ari |
| 24 | 285th | DH Travis Hafner Cle |
| 25 | 292nd | C Buster Posey SF |
| 26 | 309th | SP Madison Bumgarner SF |
| 27 | 316th | 2B Kazuo Matsui Hou |
| 28 | 333rd | C J.R. Towles Hou |
| 29 | 340th | SS Everth Cabrera SD |