| Round | Overall | Player |
|---|---|---|
| 1 | 10th | SS Troy Tulowitzki Col |
| 2 | 15th | 3B Ryan Zimmerman Was |
| 3 | 34th | 1B Kendrys Morales LAA |
| 4 | 39th | 1B Derrek Lee Bal |
| 5 | 58th | 2B Ben Zobrist TB |
| 6 | 63rd | SP Josh Johnson Fla |
| 7 | 82nd | OF Andrew McCutchen Pit |
| 8 | 87th | RP Jose Valverde Det |
| 9 | 106th | RP Andrew Bailey Oak |
| 10 | 111th | SP John Danks ChA |
| 11 | 130th | OF Jay Bruce Cin |
| 12 | 135th | SP Mark Buehrle ChA |
| 13 | 154th | OF Nick Swisher NYA |
| 14 | 159th | SP Derek Lowe Atl |
| 15 | 178th | OF Alexis Rios ChA |
| 16 | 183rd | C Ryan Doumit Pit |
| 17 | 202nd | SP Homer Bailey Cin |
| 18 | 207th | DH Nick Johnson NYA |
| 19 | 226th | 3B Brandon Wood LAA |
| 20 | 231st | OF Vernon Wells Tor |
| 21 | 250th | 2B Kelly Johnson Ari |
| 22 | 255th | SS Marcos Scutaro Bos |
| 23 | 274th | SP Jon Garland LAD |
| 24 | 279th | C Miguel Olivo Sea |
| 25 | 298th | 1B Carlos Guillen Det |
| 26 | 303rd | SP Chris Young SD |
| 27 | 322nd | OF Franklin Gutierrez Sea |
| 28 | 327th | SP Gio Gonzalez Oak |
| 29 | 346th | SP Bud Norris Hou |