| Round | Overall | Player |
|---|---|---|
| 1 | 10th | 2B Robinson Cano NYA |
| 2 | 15th | OF Curtis Granderson NYA |
| 3 | 34th | 3B Ryan Zimmerman Was |
| 4 | 39th | SP Jered Weaver LAA |
| 5 | 58th | SP Matt Cain SF |
| 6 | 63rd | OF Desmond Jennings TB |
| 7 | 82nd | SS Jimmy Rollins Phi |
| 8 | 87th | C Joe Mauer Min |
| 9 | 106th | SP Josh Beckett LAD |
| 10 | 111th | OF Carl Crawford LAD |
| 11 | 130th | OF Melvin Upton Atl |
| 12 | 135th | SP Brandon Beachy Atl |
| 13 | 154th | 1B Justin Morneau Min |
| 14 | 159th | SP Ubaldo Jimenez Cle |
| 15 | 178th | 1B Carlos Lee Mia |
| 16 | 183rd | RP Chris Perez Cle |
| 17 | 202nd | OF Alexis Rios ChA |
| 18 | 207th | SP Chris Carpenter StL |
| 19 | 226th | SP Carlos Zambrano Mia |
| 20 | 231st | RP Frank Francisco NYN |
| 21 | 250th | SP Brett Myers Cle |
| 22 | 255th | OF Jeff Francoeur KC |
| 23 | 274th | SS Ian Desmond Was |
| 24 | 279th | C Yadier Molina StL |
| 25 | 298th | SP Ryan Vogelsong SF |
| 26 | 303rd | SP Roy Oswalt Tex |
| 27 | 322nd | 2B Freddy Sanchez SF |
| 28 | 327th | OF Carlos Quentin SD |
| 29 | 346th | 3B Danny Valencia Min |