| Round | Overall | Player |
|---|---|---|
| 1 | 4th | SS Troy Tulowitzki Col |
| 2 | 21st | OF Jacoby Ellsbury Bos |
| 3 | 28th | SP Cliff Lee Phi |
| 4 | 45th | OF Nelson Cruz Tex |
| 5 | 52nd | OF Shin-Soo Choo Cin |
| 6 | 69th | 3B Aramis Ramirez Mil |
| 7 | 76th | 1B Ike Davis NYN |
| 8 | 93rd | SP Josh Beckett LAD |
| 9 | 100th | OF Carl Crawford LAD |
| 10 | 117th | RP Joel Hanrahan Bos |
| 11 | 124th | 2B Jemile Weeks Oak |
| 12 | 141st | SP Ryan Vogelsong SF |
| 13 | 148th | RP Sergio Santos Tor |
| 14 | 165th | 1B Ryan Howard Phi |
| 15 | 172nd | SP Shaun Marcum Mil |
| 16 | 189th | C Jarrod Saltalamacchia Bos |
| 17 | 196th | RP Ryan Madson Cin |
| 18 | 213th | RP Chris Perez Cle |
| 19 | 220th | C Chris Iannetta LAA |
| 20 | 237th | SP Wandy Rodriguez Pit |
| 21 | 244th | 2B Marcos Scutaro SF |
| 22 | 261st | SP Ryan Dempster Bos |
| 23 | 268th | 1B Todd Helton Col |
| 24 | 285th | OF Coco Crisp Oak |
| 25 | 292nd | SS Jason Bartlett SD |
| 26 | 309th | SP Carl Pavano Min |
| 27 | 316th | RP Jonathan Broxton Cin |
| 28 | 333rd | SP Jorge de la Rosa Col |
| 29 | 340th | 3B Chone Figgins Sea |