| Round | Overall | Player |
|---|---|---|
| 1 | 10th | 3B Evan Longoria TB |
| 2 | 15th | 2B Ian Kinsler Tex |
| 3 | 34th | 1B Paul Konerko ChA |
| 4 | 39th | SP Jered Weaver LAA |
| 5 | 58th | SS Asdrubal Cabrera Cle |
| 6 | 63rd | SP Josh Johnson Tor |
| 7 | 82nd | SP Adam Wainwright StL |
| 8 | 87th | C Miguel Montero Ari |
| 9 | 106th | OF Chris Young Oak |
| 10 | 111th | 3B Mike Young Phi |
| 11 | 130th | OF Brennan Boesch Det |
| 12 | 135th | SP Ervin Santana KC |
| 13 | 154th | OF Mark Trumbo LAA |
| 14 | 159th | RP Brandon League LAD |
| 15 | 178th | SP Jair Jurrjens Atl |
| 16 | 183rd | RP Rafael Betancourt Col |
| 17 | 202nd | SS Stephen Drew Bos |
| 18 | 207th | C Russell Martin NYA |
| 19 | 226th | SP Brett Myers Cle |
| 20 | 231st | 1B Jesus Guzman SD |
| 21 | 250th | SP Jake Peavy ChA |
| 22 | 255th | OF Emilio Bonifacio Mia |
| 23 | 274th | 2B Jose Altuve Hou |
| 24 | 279th | OF Vernon Wells LAA |
| 25 | 298th | SP Roy Oswalt Tex |
| 26 | 303rd | OF Denard Span Was |
| 27 | 322nd | DH Jim Thome Bal |
| 28 | 327th | SP James Mcdonald Pit |
| 29 | 346th | 3B Chris Johnson Ari |