| Round | Overall | Player |
|---|---|---|
| 1 | 8th | 1B Joey Votto Cin |
| 2 | 17th | 3B Adrian Beltre Tex |
| 3 | 32nd | OF Matt Holliday StL |
| 4 | 41st | SP Felix Hernandez Sea |
| 5 | 56th | SP James Shields KC |
| 6 | 65th | 2B Brandon Phillips Cin |
| 7 | 80th | SP Tommy Hanson LAA |
| 8 | 89th | OF Melvin Upton Atl |
| 9 | 104th | SP Yu Darvish Tex |
| 10 | 113th | RP J.J. Putz Ari |
| 11 | 128th | SS Jhonny Peralta Det |
| 12 | 137th | SP Jaime Garcia StL |
| 13 | 152nd | OF Nick Markakis Bal |
| 14 | 161st | OF Drew Stubbs Cle |
| 15 | 176th | RP Huston Street SD |
| 16 | 185th | SP Trevor Cahill Ari |
| 17 | 200th | 1B Justin Morneau Min |
| 18 | 209th | SP Chad Billingsley LAD |
| 19 | 224th | SP Mike Leake Cin |
| 20 | 233rd | DH Edwin Encarnacion Tor |
| 21 | 248th | 2B Dan Murphy NYN |
| 22 | 257th | SS Jed Lowrie Hou |
| 23 | 272nd | 3B Brent Morel CHA |
| 24 | 281st | OF Lorenzo Cain KC |
| 25 | 296th | C John Buck Mia |
| 26 | 305th | C Nick Hundley SD |
| 27 | 320th | SP Scott Baker ChN |
| 28 | 329th | OF Michael Brantley Cle |
| 29 | 344th | 1B Aubrey Huff SF |