| Round | Overall | Player |
|---|---|---|
| 1 | 9th | OF Jose Bautista Tor |
| 2 | 16th | 1B Prince Fielder Det |
| 3 | 33rd | 2B Ben Zobrist TB |
| 4 | 40th | OF Hunter Pence SF |
| 5 | 57th | SP Jon Lester Bos |
| 6 | 64th | 3B Kevin Youkilis NYA |
| 7 | 81st | RP Mariano Rivera NYA |
| 8 | 88th | OF Shane Victorino Bos |
| 9 | 105th | C Jesus Montero Sea |
| 10 | 112th | SS Alexei Ramirez ChA |
| 11 | 129th | RP Andrew Bailey Bos |
| 12 | 136th | OF Nick Swisher Cle |
| 13 | 153rd | SP Derek Holland Tex |
| 14 | 160th | SP Mark Buehrle Tor |
| 15 | 177th | SP Ubaldo Jimenez Cle |
| 16 | 184th | 3B Mike Moustakas KC |
| 17 | 201st | 2B Kelly Johnson Tor |
| 18 | 208th | C Kurt Suzuki Was |
| 19 | 225th | SP Gavin Floyd ChA |
| 20 | 232nd | RP Sean Marshall Cin |
| 21 | 249th | SS Ian Desmond Was |
| 22 | 256th | OF Jason Kubel Ari |
| 23 | 273rd | OF Alfonso Soriano ChN |
| 24 | 280th | SP Rick Porcello Det |
| 25 | 297th | 1B James Loney TB |
| 26 | 304th | SP Ted Lilly LAD |
| 27 | 321st | SP Randy Wolf Mil |
| 28 | 328th | 3B Scott Rolen Cin |
| 29 | 345th | SP Philip Hughes NYA |