| Round | Overall | Player |
|---|---|---|
| 1 | 5th | OF Jose Bautista Tor |
| 2 | 20th | OF Justin Upton Ari |
| 3 | 29th | SP Jered Weaver LAA |
| 4 | 44th | SP James Shields KC |
| 5 | 53rd | 2B Brandon Phillips Cin |
| 6 | 68th | SP Josh Johnson Tor |
| 7 | 77th | SS J.J. Hardy Bal |
| 8 | 92nd | RP Jordan Walden LAA |
| 9 | 101st | C Miguel Montero Ari |
| 10 | 116th | OF Mike Morse Was |
| 11 | 125th | 3B Ryan Roberts TB |
| 12 | 140th | 1B Carlos Pena TB |
| 13 | 149th | OF Delmon Young Det |
| 14 | 164th | OF Nick Swisher Cle |
| 15 | 173rd | RP Javy Guerra LAD |
| 16 | 188th | SP Justin Masterson Cle |
| 17 | 197th | 1B Gaby Sanchez Pit |
| 18 | 212th | SP Ivan Nova NYA |
| 19 | 221st | 3B David Freese StL |
| 20 | 236th | SS Mike Aviles Cle |
| 21 | 245th | 2B Dan Murphy NYN |
| 22 | 260th | OF Chris Parmelee Min |
| 23 | 269th | SP Rick Porcello Det |
| 24 | 284th | OF Emilio Bonifacio Mia |
| 25 | 293rd | SP Carl Pavano Min |
| 26 | 308th | C Kurt Suzuki Was |
| 27 | 317th | SP Glen Perkins Min |
| 28 | 332nd | SP Luke Hochevar KC |
| 29 | 341st | SP Tim Stauffer SD |