| Round | Overall | Player |
|---|---|---|
| 1 | 11th | 1B Prince Fielder Det |
| 2 | 14th | OF Curtis Granderson NYA |
| 3 | 35th | OF Alex Gordon KC |
| 4 | 38th | C Mike Napoli Bos |
| 5 | 59th | SP Matt Cain SF |
| 6 | 62nd | 3B Kevin Youkilis NYA |
| 7 | 83rd | SP C.J. Wilson LAA |
| 8 | 86th | RP Heath Bell Ari |
| 9 | 107th | OF Shane Victorino Bos |
| 10 | 110th | SP Ervin Santana KC |
| 11 | 131st | SP Mark Buehrle Tor |
| 12 | 134th | SP Jaime Garcia StL |
| 13 | 155th | SP John Danks ChA |
| 14 | 158th | 2B Chase Utley Phi |
| 15 | 179th | RP Chris Perez Cle |
| 16 | 182nd | RP Rafael Betancourt Col |
| 17 | 203rd | OF Martin Prado Atl |
| 18 | 206th | SS Erick Aybar LAA |
| 19 | 227th | SS Zach Cozart Cin |
| 20 | 230th | 2B Gordon Beckham ChA |
| 21 | 251st | 1B Mitch Moreland Tex |
| 22 | 254th | OF Eric Thames Sea |
| 23 | 275th | C Devin Mesoraco Cin |
| 24 | 278th | OF Alfonso Soriano ChN |
| 25 | 299th | 3B Placido Polanco Mia |
| 26 | 302nd | SP Bud Norris Hou |
| 27 | 323rd | DH Edwin Encarnacion Tor |
| 28 | 326th | SP Philip Humber ChA |
| 29 | 347th | 2B Darwin Barney ChN |