| Round | Overall | Player |
|---|---|---|
| 1 | 5th | OF Ronald Acuna Jr. Atl |
| 2 | 20th | 1B Rhys Hoskins Phi |
| 3 | 29th | SP Corey Kluber Cle |
| 4 | 44th | SP Blake Snell TB |
| 5 | 53rd | OF Justin Upton LAA |
| 6 | 68th | SP Clayton Kershaw LAD |
| 7 | 77th | SS Paul DeJong StL |
| 8 | 92nd | 2B Jurickson Profar SD |
| 9 | 101st | 3B Miguel Andújar NYA |
| 10 | 116th | OF David Peralta Ari |
| 11 | 125th | C Wilson Ramos NYN |
| 12 | 140th | SP Charlie Morton TB |
| 13 | 149th | OF Gregory Polanco Pit |
| 14 | 164th | SP Mike Foltynewicz Atl |
| 15 | 173rd | 1B Justin Smoak Tor |
| 16 | 188th | SS Tim Anderson ChA |
| 17 | 197th | 2B Niko Goodrum Det |
| 18 | 212th | SP Collin McHugh Hou |
| 19 | 221st | 3B Jung Ho Kang Pit |
| 20 | 236th | OF Hunter Renfroe TB |
| 21 | 245th | SP Michael Pineda Min |
| 22 | 260th | OF Ketel Marte Ari |
| 23 | 269th | SP Marcus Stroman NYN |
| 24 | 284th | SP Brad Peacock Hou |
| 25 | 293rd | 3B Kyle Seager Sea |
| 26 | 308th | SS Didi Gregorius NYA |
| 27 | 317th | C Omar Narváez Sea |
| 28 | 332nd | SP Brad Keller KC |
| 29 | 341st | SP Corbin Burnes Mil |