| Round | Overall | Player |
|---|---|---|
| 1 | 11th | DH J.D. Martinez Bos |
| 2 | 14th | 1B Freddie Freeman Atl |
| 3 | 35th | SP Gerrit Cole Hou |
| 4 | 38th | SS Jean Segura Phi |
| 5 | 59th | OF David Dahl Col |
| 6 | 62nd | 3B Vladimir Guerrero Jr Tor |
| 7 | 83rd | SP Jose Berrios Min |
| 8 | 86th | 3B Rafael Devers Bos |
| 9 | 107th | 3B Yoan Moncada ChA |
| 10 | 110th | OF Starling Marte Pit |
| 11 | 131st | OF Wil Myers SD |
| 12 | 134th | SP Rick Porcello Bos |
| 13 | 155th | SP Jose Quintana ChN |
| 14 | 158th | SP Eduardo Rodriguez Bos |
| 15 | 179th | OF Kyle Schwarber ChN |
| 16 | 182nd | RP Matt Barnes Bos |
| 17 | 203rd | RP Arodys Vizcaino Atl |
| 18 | 206th | SP Joe Musgrove Pit |
| 19 | 227th | RP Matthew Strahm SD |
| 20 | 230th | C Danny Jansen Tor |
| 21 | 251st | 3B Johan Camargo Atl |
| 22 | 254th | OF Randal Grichuk Tor |
| 23 | 275th | SS Luis Urias Mil |
| 24 | 278th | OF Marwin Gonzalez Min |
| 25 | 299th | SP Luke Weaver Ari |
| 26 | 302nd | SP Zach Eflin Phi |
| 27 | 323rd | C John Hicks Det |
| 28 | 326th | 2B Ian Kinsler SD |
| 29 | 347th | 1B Ji-Man Choi TB |