| Round | Overall | Player |
|---|---|---|
| 1 | 6th | SS Fernando Tatis Jr. SD |
| 2 | 19th | 3B Jose Ramirez Cle |
| 3 | 30th | 2B D.J. LeMahieu NYA |
| 4 | 43rd | SP Yu Darvish SD |
| 5 | 54th | OF Luis Robert ChA |
| 6 | 67th | C J.T. Realmuto Phi |
| 7 | 78th | DH J.D. Martinez Bos |
| 8 | 91st | SP Jose Berrios Tor |
| 9 | 102nd | 1B Dom Smith NYN |
| 10 | 115th | 1B Andrew Vaughn ChA |
| 11 | 126th | SP Dylan Bundy LAA |
| 12 | 139th | SP Charlie Morton Atl |
| 13 | 150th | OF Mike Yastrzemski SF |
| 14 | 163rd | SP Lance McCullers Hou |
| 15 | 174th | SP Joe Musgrove SD |
| 16 | 187th | OF Alex Verdugo Bos |
| 17 | 198th | RP Adam Ottavino Bos |
| 18 | 211th | 3B Ke'Bryan Hayes Pit |
| 19 | 222nd | RP Matt Barnes Bos |
| 20 | 235th | 2B Jonathan India Cin |
| 21 | 246th | SP Kevin Gausman SF |
| 22 | 259th | RP Amir Garrett Cin |
| 23 | 270th | SP Tyler Mahle Cin |
| 24 | 283rd | 1B Jay Bruce Ret |
| 25 | 294th | OF Justin Upton LAA |
| 26 | 307th | OF Alex Kirilloff Min |
| 27 | 318th | SP Anthony DeSclafani SF |
| 28 | 331st | SS Willi Castro Det |
| 29 | 342nd | C Wilson Ramos Det |