| Round | Overall | Player |
|---|---|---|
| 1 | 1st | OF Ronald Acuna Jr. Atl |
| 2 | 24th | SS Trevor Story Col |
| 3 | 25th | 3B Anthony Rendon LAA |
| 4 | 48th | SP Blake Snell SD |
| 5 | 49th | SP Tyler Glasnow TB |
| 6 | 72nd | C J.T. Realmuto Phi |
| 7 | 73rd | 2B Keston Hiura Mil |
| 8 | 96th | SP Julio Urías LAD |
| 9 | 97th | SP Zac Gallen Ari |
| 10 | 120th | RP James Karinchak Cle |
| 11 | 121st | RP Edwin Diaz NYN |
| 12 | 144th | DH J.D. Martinez Bos |
| 13 | 145th | OF Trent Grisham SD |
| 14 | 168th | SP Nate Pearson Tor |
| 15 | 169th | OF Byron Buxton Min |
| 16 | 192nd | OF Julio Rodriguez Sea |
| 17 | 193rd | SP AJ Puk Oak |
| 18 | 216th | SP Nathan Eovaldi Bos |
| 19 | 217th | SP Chris Sale Bos |
| 20 | 240th | OF Joc Pederson ChN |
| 21 | 241st | 1B Nate Lowe Tex |
| 22 | 264th | SS Miguel Rojas Mia |
| 23 | 265th | SP Casey Mize Det |
| 24 | 288th | SP Michael Kopech ChA |
| 25 | 289th | 2B Kolten Wong Mil |
| 26 | 312th | SP Spencer Howard Phi |
| 27 | 313th | SP Logan Gilbert Sea |
| 28 | 336th | OF Gregory Polanco Pit |
| 29 | 337th | SS C.J. Abrams SD |