| Round | Overall | Player |
|---|---|---|
| 1 | 2nd | SS Fernando Tatis Jr. SD |
| 2 | 23rd | 3B Rafael Devers Bos |
| 3 | 26th | SP Walker Buehler LAD |
| 4 | 47th | 1B Rhys Hoskins Phi |
| 5 | 50th | SP Sixto Sánchez Mia |
| 6 | 71st | 2B Ketel Marte Ari |
| 7 | 74th | SP Max Fried Atl |
| 8 | 95th | OF Austin Meadows TB |
| 9 | 98th | RP Brad Hand Tor |
| 10 | 119th | OF Alex Verdugo Bos |
| 11 | 122nd | SP Sonny Gray Cin |
| 12 | 143rd | C Gary Sanchez NYA |
| 13 | 146th | RP Alex Colome Min |
| 14 | 167th | OF Franmil Reyes Cle |
| 15 | 170th | SP Eduardo Rodriguez Bos |
| 16 | 191st | OF Max Kepler Min |
| 17 | 194th | SP Cristian Javier Hou |
| 18 | 215th | SS Didi Gregorius Phi |
| 19 | 218th | SP Sean Manaea Oak |
| 20 | 239th | OF David Dahl Tex |
| 21 | 242nd | SP Dylan Cease ChA |
| 22 | 263rd | C Christian Vazquez Bos |
| 23 | 266th | 2B Jonathan Schoop Det |
| 24 | 287th | 1B Evan White Sea |
| 25 | 290th | SP Framber Valdez Hou |
| 26 | 311th | 3B Carter Kieboom Was |
| 27 | 314th | OF Adam Duvall Mia |
| 28 | 335th | SP Jon Lester Was |
| 29 | 338th | 2B Ha-seong Kim SD |