| Round | Overall | Player |
|---|---|---|
| 1 | 2nd | OF Ronald Acuna Jr. Atl |
| 2 | 23rd | OF Fernando Tatis Jr. SD |
| 3 | 26th | SS Bobby Witt Jr. KC |
| 4 | 47th | SP Jacob deGrom Tex |
| 5 | 50th | OF Eloy Jimenez ChA |
| 6 | 71st | SS Wander Franco TB |
| 7 | 74th | SP Kevin Gausman Tor |
| 8 | 95th | OF MJ Melendez KC |
| 9 | 98th | OF Tyler O'Neill StL |
| 10 | 119th | 1B Andrew Vaughn ChA |
| 11 | 122nd | OF Bryce Harper Phi |
| 12 | 143rd | SP Freddy Peralta Mil |
| 13 | 146th | SP Chris Sale Bos |
| 14 | 167th | C Cal Raleigh Sea |
| 15 | 170th | 2B Jose Altuve Hou |
| 16 | 191st | RP Alexis Diaz Cin |
| 17 | 194th | SP Tyler Glasnow TB |
| 18 | 215th | 1B Darick Hall Phi |
| 19 | 218th | SP Cal Quantrill Cle |
| 20 | 239th | RP Jose Leclerc Tex |
| 21 | 242nd | 2B Luis Urias Mil |
| 22 | 263rd | RP Paul Sewald Ari |
| 23 | 266th | SS Ramon Urias Bal |
| 24 | 287th | RP Alex Lange Det |
| 25 | 290th | SP Triston McKenzie Cle |
| 26 | 311th | 3B Hunter Dozier KC |
| 27 | 314th | SP Aaron Civale TB |
| 28 | 335th | SP Zach Plesac Cle |
| 29 | 338th | RP Scott McGough Ari |