| Week | Add | Drop |
| Pre-Season |
Round 1: RP Yimi Garcia - Tor Round 2: 1B Giovanny Urshela - Det Round A: OF Parker Meadows - Det Round B: SP Cade Horton - ChN |
Round A: 1B Brandon Belt - F/A Round B: 2B Mike Moustakas - F/A |
| Week 1 |
Round 1: RP Jason Foley - Det Round 2: 3B Trey Lipscomb - Was |
Round 2: RP Yimi Garcia - Tor |
| Week 2 |
Round 1: SP Edward Cabrera - Mia Round 2: RP James McArthur - KC |
Round 1: SP Shane Bieber - Cle |
| Week 3 |
Round 1: OF Joey Loperfido - Hou Round 2: SP Lance Lynn - StL |
Round 1: RP Jose Leclerc - Tex Round 2: RP Alex Lange - Det |
| Week 4 |
Round 2: OF Joey Gallo - Was |
Round 1: 1B Giovanny Urshela - Det Round 2: 3B Anthony Rendon - LAA Round 2: 3B Trey Lipscomb - Was |
| Week 5 |
Round 1: SP Simeon Woods Richardson - Min Round 2: 1B Ty France - Sea |
Round 2: OF Joey Gallo - Was |
| Week 6 |
Round 1: RP Garrett Whitlock - Bos Round 2: C Connor Wong - Bos |
Round 1: 1B Jose Abreu - Hou |
| 1st Team | 2nd Team |
| Pre-Season | |
| Buffalo Horseheads | The Shogun of Harlem |
|
Round 6, 9th Pick (SS Trevor Story Bos) |
SS
Ezequiel Tovar
Col Round 15, 3rd Pick (2B Brendan Rodgers Col) Round 19, 3rd Pick (3B Anthony Rendon LAA) |
| Pre-Season | |
| Buffalo Horseheads | Amarillo Sod Poodles |
|
Round 15, 9th Pick (SP Ranger Suarez Phi) Round 17, 9th Pick (C Elias Diaz Col) |
Round 14, 4th Pick (RP Jose Leclerc Tex) |
| Pre-Season | |
| Buffalo Horseheads | The Shogun of Harlem |
|
Round 3, 9th Pick (OF Anthony Santander Bal) Round 4, 9th Pick (2B Jorge Polanco Sea) |
Round 16, 3rd Pick (OF Mitch Haniger Sea) Round 17, 3rd Pick (DH Mitch Garver Sea) |
| Pre-Season | |
| Buffalo Horseheads | Amarillo Sod Poodles |
|
OF
James Outman
LAD Round 19, 9th Pick (SP Tylor Megill NYN) |
Round 9, 4th Pick (1B Jose Abreu Hou) |