| Week | Add | Drop |
| Pre-Season |
Round 1: 2B Willi Castro - ChN Round 2: 1B Jeimer Candelario - Cin Round 3: C Jonah Heim - Tex Round A: 1B Bryce Eldridge - SF Round B: OF Emmanuel Rodriguez - Min |
Round 3: SS Jordan Lawlar - Ari Round A: 1B Alex Kirilloff - Min Round B: C Ryan Jeffers - Min |
| Week 1 |
Round 1: OF Trevor Larnach - Min Round 2: RP Camilo Doval - NYA Round 3: SP Jordan Hicks - Bos |
Round 2: 1B Jose Miranda - Min Round 3: RP Camilo Doval - NYA |
| Week 2 |
Round 2: 2B Brendan Rodgers - Hou Round 3: OF Trent Grisham - NYA |
Round 2: 2B Willi Castro - ChN Round 3: OF Trevor Larnach - Min |
| Week 3 |
Round 1: OF Mike Yastrzemski - KC Round 2: 1B Ty France - Tor Round 3: SP Ben Brown - ChN |
Round 1: OF Trent Grisham - NYA Round 2: 1B Jeimer Candelario - Cin Round 3: SP Jordan Hicks - Bos |
| Week 4 |
Round 1: SP Joe Boyle - TB Round 2: SP Cade Horton - ChN Round 3: SP Hayden Wesneski - Hou |
Round 1: 2B Christian Moore - LAA Round 2: SP Eduardo Rodriguez - Ari Round 3: SP Joe Boyle - TB |
| Week 5 |
Round 1: 3B Noelvi Marte - Cin Round 2: SP Ryan Gusto - Mia Round 3: 3B Ben Williamson - Sea |
Round 1: 1B Ty France - Tor Round 2: SP Ben Brown - ChN Round 3: 2B Brendan Rodgers - Hou |
| Week 6 |
Round 1: OF Andy Pages - LAD Round 2: SS Leodalis De Vries - Oak Round 3: SP Tanner Houck - Bos |
Round 1: 3B Ben Williamson - Sea Round 2: OF JJ Bleday - Oak Round 3: SP Ryan Gusto - Mia |
| Week 7 |
Round 1: C Dalton Rushing - LAD Round 2: OF Colby Thomas - Oak Round 3: 3B Brett Baty - NYN |
Round 1: RP Justin Martinez - Ari Round 2: SP Hayden Wesneski - Hou Round 3: SP Jameson Taillon - ChN |
| Week 8 |
Round 1: SP Joe Boyle - TB Round 3: RP Jordan Romano - Phi |
Round 1: SP Tanner Houck - Bos Round 3: C Jonah Heim - Tex |
| Week 9 |
Round 1: OF Chase DeLauter - Cle Round 2: SS Cole Young - Sea Round 3: OF Alejandro Osuna - Tex |
Round 1: OF Mike Yastrzemski - KC Round 2: OF Nick Castellanos - Phi Round 2: SP Joe Boyle - TB |
| Week 10 |
Round 1: OF Jesus Sanchez - Hou Round 2: SP Joe Boyle - TB | |
| Week 11 |
Round 1: OF Jerar Encarnación - SF Round 2: SS Kevin McGonigle - Det Round 3: C Henry Davis - Pit |
Round 2: SS Cole Young - Sea Round 3: C J.T. Realmuto - Phi |
| Week 12 |
Round 1: SP Walker Buehler - Phi Round 2: SS Jesus Made - Mil Round 3: SP Clayton Kershaw - LAD |
Round 1: SP JP Sears - SD Round 2: OF Jerar Encarnación - SF Round 3: OF Alejandro Osuna - Tex |
| Week 13 |
Round 1: SP Lucas Giolito - Bos Round 2: OF Mickey Moniak - Col |
Round 1: RP Jordan Romano - Phi Round 2: OF Jesus Sanchez - Hou |
| Week 14 |
Round 1: 2B Isaac Collins - Mil Round 2: SP Travis Sykora - Was |
Round 1: OF Mickey Moniak - Col Round 2: 2B Hyeseong Kim - LAD |
| Week 15 |
Round 1: OF Brenton Doyle - Col Round 2: 2B Nick Gonzales - Pit Round 3: SP Luis Gil - NYA |
Round 1: C Henry Davis - Pit Round 2: 2B Isaac Collins - Mil Round 3: 3B Brett Baty - NYN |
| Week 16 |
Round 1: SS Josue De Paula - LAD Round 2: C Josue Briceno - Det Round 3: OF Taylor Trammell - Hou |
Round 1: OF Colby Thomas - Oak Round 2: SP Joe Boyle - TB Round 3: OF Brenton Doyle - Col |
| Week 18 |
Round 1: OF Mickey Moniak - Col Round 2: SP Kade Anderson - Sea Round 3: SS Avia Arquette - Mia |
Round 1: 2B Nick Gonzales - Pit Round 2: OF Taylor Trammell - Hou Round 3: RP Orion Kerkering - Phi |
| Week 19 |
Round 1: SP Edward Cabrera - Mia Round 2: OF Yanquiel Fernandez - Col Round 3: RP Ryan Helsley - NYN |
Round 1: SP Travis Sykora - Was Round 2: SP Walker Buehler - Phi Round 3: SS J.P. Crawford - Sea |
| Week 20 |
Round 1: OF Jakob Marsee - Mia Round 2: OF Carson Benge - NYN Round 3: OF Jordan Walker - StL |
Round 1: OF Yanquiel Fernandez - Col Round 2: RP Raisel Iglesias - Atl Round 3: OF Mickey Moniak - Col |
| Week 22 |
Round 1: OF Brenton Doyle - Col Round 2: C Ivan Herrera - StL Round 3: 1B Andrew Vaughn - Mil |
Round 1: OF Jordan Walker - StL Round 2: SP Cade Horton - ChN Round 3: SP Edward Cabrera - Mia |
| Week 24 |
Round 1: 2B Jeremiah Jackson - Bal |
Round 1: RP Ryan Helsley - NYN |
| 1st Team | 2nd Team |
| Week 9 | |
| Acuna Machado | Fightin Phils |
|
OF
Tommy Edman
LAD |
SP
JP Sears
Oak |
| Week 9 | |
| Acuna Machado | Santa’s Stars |
|
SP
Sonny Gray
StL |
|
| Week 9 | |
| Acuna Machado | Fightin Phils |
|
SP
Jacob deGrom
Tex |
SP
Jacob Misiorowski
Mil |
| Week 10 | |
| Acuna Machado | The Plantation |
|
OF
Christian Yelich
Mil |
|
| Week 10 | |
| Acuna Machado | Bad Reputation |
|
SP
Ranger Suarez
Phi |
|
| Week 14 | |
| Acuna Machado | Caught in a run down |
|
SP
Zach Eflin
Bal SP George Kirby Sea OF Andy Pages LAD 1B Nick Kurtz Oak |
SP
Tarik Skubal
Det SP Jackson Jobe Det RP Orion Kerkering Phi 2B Hyeseong Kim LAD |